Results 11 to 20 of about 853,787 (154)

Microbial Biotechnology at the Frontiers of Innovation: Engineering Solutions for Health, Industry and Sustainability. [PDF]

Microb Biotechnol
Microbial Biotechnology, Volume 19, Issue 9, September 2026.
Bernal P, Ramos JL.
europepmc   +2 more sources

Metabolic Footprint of Drosophila S2 Cells: Findings During the Production of a Recombinant Rabies Virus Glycoprotein. [PDF]

Biotechnol J
Graphical Abstract and Lay Summary To further increase protein expression, it is imperative to improve cellular performance, a process intrinsically linked to cell metabolism. Hence, a metabolic footprint of Drosophila S2 cells, both recombinant‐ and wild‐types, was performed to enhance the production of the recombinant rabies virus glycoprotein ...
Decarli MC, Dos Santos DP, Correia DM, de Azevedo AG, Suazo CAT, Moraes ÂM, Astray RM.   +6 more
europepmc   +2 more sources

Hyper-Enriched Anti-RSV Immunoglobulins Nasally Administered: A Promising Approach for Respiratory Syncytial Virus Prophylaxis

Frontiers in Immunology, 2021
Respiratory syncytial virus (RSV) is a public health concern that causes acute lower respiratory tract infection. So far, no vaccine candidate under development has reached the market and the only licensed product to prevent RSV infection in at-risk ...
Emilie Jacque, Claire Chottin, Daphné Laubreton, Michel Nogre, Cécile Ferret, Sandrine de Marcos, Linda Baptista, Carole Drajac, Philippe Mondon, Christophe De Romeuf, Marie-Anne Rameix-Welti, Marie-Anne Rameix-Welti, Jean-François Eléouët, Sami Chtourou, Sabine Riffault, Gérald Perret, Delphyne Descamps   +16 more
doaj   +1 more source

Advances in purification of SARS-CoV-2 spike ectodomain protein using high-throughput screening and non-affinity methods

Scientific Reports, 2022
The spike (S) glycoprotein of the pandemic virus, SARS-CoV-2, is a critically important target of vaccine design and therapeutic development. A high-yield, scalable, cGMP-compliant downstream process for the stabilized, soluble, native-like S protein ...
Nicole Cibelli, Gabriel Arias, McKenzie Figur, Shireen S. Khayat, Kristin Leach, Ivan Loukinov, William Shadrick, Watchalee Chuenchor, Yaroslav Tsybovsky, Vaccine Production Program Analytical Development, Krishana Gulla, Daniel B. Gowetski   +11 more
doaj   +1 more source

Allogeneic cell therapy bioprocess economics and optimisation: Single-use cell expansion technologies. [PDF]

, 2014
For allogeneic cell therapies to reach their therapeutic potential, challenges related to achieving scalable and robust manufacturing processes will need to be addressed. A particular challenge is producing lot-sizes capable of meeting commercial demands
Warren, K, Sally Hassan, Ana S. Simaria, Vanek, P, Varadaraju, H, Jon Rowley, Philip Vanek, Rowley, J, Farid, SS, Kim Warren, Hassan, S, Hemanthram Varadaraju, Simaria, AS, Suzanne S. Farid   +13 more
core   +1 more source

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +3 more sources

Scaling-up vaccine production: implementation aspects of a biomass growth observer and controller [PDF]

, 2009
This study considers two aspects of the implementation of a biomass growth observer and specific growth rate controller in scale-up from small- to pilot-scale bioreactors towards a feasible bulk production process for whole-cell vaccine against whooping ...
IJssel, J., van den, Straten, G., van, van den IJssel, J., Boxtel, A.J.B., van, Pol, L.A., van der, Soons, Z.I.T.A., van der Pol, L.A., van Boxtel, A.J.B., van Straten, G.   +8 more
core   +1 more source

Vaccination reduces the viral load and the risk of transmission of Jembrana disease virus in Bali cattle [PDF]

, 2009
The efficacy of a tissue-derived vaccine, which is currently used in Indonesia to control the spread of Jembrana disease in Bali cattle, was determined by quantifying the viral load in plasma following experimental infection with Jembrana disease virus ...
Wilcox, G.E., Ditcham, W.G.F., Lewis, Joshua R., Wilcox, Graham E., Desport, Moira, Hartaningsih, N., Desport, M., Dobson, Robert J., Ditcham, William G.F., Lewis, J.R., Dobson, R.J., Hartaningsih, Nining   +11 more
core   +1 more source

Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence [PDF]

, 2012
Foremost amongst the diseases preventable by vaccination is influenza. Worldwide, influenza virus infection is associated with serious adverse events leading to hospitalization, debilitating complications, and death in elderly individuals ...
Assir N, Lang, Pierre-Olivier, Govind, Sheila, Aspinall R, Mendes A, Mendes, Aline, Socquet, Jennifer, Govind S, Socquet J, Assir, Noémie, Lang PO, Aspinall, Richard   +11 more
core   +1 more source

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus [PDF]

, 2010
Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively.
Dubuquoy, Catherine, C., Eléouët, Jean-François, Soulestin, Marion, Deville, Sébastien, Durand, Guillaume, Meyer, Gilles, G., Bernard, Julie, Bernadet, Philippe, Bernardet, Philippe, Petit-Camurdan, Agnès, Schwartz-Cornil, Isabelle, Riffault, Sabine, Dubosclard, Virginie, Eleouet, Jean Francois, J. F., Meyer, Gilles, Castagné, Nathalie, Deplanche, Martine, Bernex, Florence, Dubuquoy, Catherine   +18 more
core   +1 more source