Results 111 to 120 of about 1,490,578 (344)
Implications of viral transmitted/founder (T/F) dynamics on vaccine development [PDF]
, 2020 Alexander I. Mosa
openalex +1 more source
Recent Developments in Vaccines for Viral Diseases [PDF]
, 2023 Yasir Waheed +2 more
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Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections
Frontiers in Immunology, 2018 For many years, the focus of prophylactic vaccines was to elicit neutralizing antibodies, but it has become increasingly evident that T cell-mediated immunity plays a central role in controlling persistent viral infections such as with human ...
E. Panagioti +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun +12 more
wiley +1 more source
Matrix and Backstage: Cellular Substrates for Viral Vaccines
Viruses, 2014 Vaccines are complex products that are manufactured in highly dynamic processes. Cellular substrates are one critical component that can have an enormous impact on reactogenicity of the final preparation, level of attenuation of a live virus, yield of ...
I. Jordan, V. Sandig
semanticscholar +1 more source
Advanced Science, EarlyView.The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan +9 more
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Factors Affecting the Use and Efficacy of Viral Vaccines [Abridged] [PDF]
, 1969 A Kelly
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2320. Novel checkpoint modifier lowers T cell activation threshold and enhances and broadens vaccine-induced responses to chronic viral infections [PDF]
, 2022 Mohadeseh Hasanpourghadi +5 more
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