Results 11 to 20 of about 657,629 (304)

Clinical Applications and Immunological Aspects of Electroporation-Based Therapies

Vaccines, 2021
Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently
Jean Carlos dos Santos da Luz, Fernanda Antunes, Maria Alejandra Clavijo-Salomon, Emanuela Signori, Nayara Gusmão Tessarollo, Bryan E. Strauss   +5 more
doaj   +1 more source

Low Transmission of Chikungunya Virus by Aedes aegypti from Vientiane Capital, Lao PDR

Pathogens, 2022
In 2012–2013, chikungunya virus (CHIKV) was the cause of a major outbreak in the southern part of Lao People’s Democratic Republic (Lao PDR). Since then, only a few imported cases, with isolates belonging to different lineages, were recorded between 2014
Elodie Calvez, Elliott F. Miot, Sitsana Keosenhom, Vaekey Vungkyly, Souksakhone Viengphouthong, Phaithong Bounmany, Paul T. Brey, Sébastien Marcombe, Marc Grandadam   +8 more
doaj   +1 more source

Comparative Analysis of Six Adeno-Associated Viral Vector Serotypes in Mouse Inferior Colliculus and Cerebellum. [PDF]

eNeuro
Witteveen I, Balmer T.
europepmc   +3 more sources

Purulent-septic infections in puerperas. Part 2. Clinical and pathogenetic characteristics of nosological forms, etiology and antibiotic resistance (literature review)

Журнал микробиологии, эпидемиологии и иммунобиологии, 2022
Despite the improvement of the obstetric care system, purulent-septic infections (PSI) of puerperas and the associated maternal mortality do not lose relevance at the present time.
S. S. Smirnova, I. A. Egorov, A. A. Golubkova   +2 more
doaj   +1 more source

Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy

Molecular Therapy: Methods & Clinical Development, 2021
To develop safer retroviral murine leukemia virus (MLV)-based vectors, we previously mutated and re-engineered the MLV integrase: the W390A mutation abolished the interaction with its cellular tethering factors, BET proteins, and a retargeting peptide ...
Dominique Van Looveren, Giorgia Giacomazzi, Irina Thiry, Maurilio Sampaolesi, Rik Gijsbers   +4 more
doaj   +1 more source

Assembly and functional analysis of an S/MAR based episome with the cystic fibrosis transmembrane conductance regulator gene [PDF]

, 2018
Improving the efficacy of gene therapy vectors is still an important goal toward the development of safe and efficient gene therapy treatments. S/MAR (scaffold/matrix attached region)-based vectors are maintained extra-chromosomally in numerous cell ...
Ascenzioni, Fiorentina, Castellani, Stefano, Cavinato, Luca, Cimino, Giuseppe, Conese, Massimo, De Rocco, Davide, Guarnieri, Simone, Mariggiò, Maria A., Morini, Elena, Pompili, Barbara, Porto, Paola Del   +10 more
core   +7 more sources

Blood-feeding, susceptibility to infection with Schmallenberg virus and phylogenetics of Culicoides (Diptera: Ceratopogonidae) from the United Kingdom

Parasites & Vectors, 2018
Background Culicoides biting midges (Diptera: Ceratopogonidae) are responsible for the biological transmission of internationally important arboviruses of livestock.
James Barber, Lara E. Harrup, Rhiannon Silk, Eva Veronesi, Simon Gubbins, Katarzyna Bachanek-Bankowska, Simon Carpenter   +6 more
doaj   +1 more source

An Improved Protocol for the Production of Lentiviral Vectors

STAR Protocols, 2020
Summary: Lentiviral vectors are an ideal gene-delivery system for large gene-editing tools, such as the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 system, due to their high packaging capacity and broad tropism.
Logan Y. Brown, Wendy Dong, Boris Kantor
doaj   +1 more source

Progress in the use of adeno-associated viral vectors for gene therapy [PDF]

, 2004
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Braun-Falco, M., Buning, H., Hallek, M.
core   +1 more source

Clinical and Epidemiological Features of Actual Tick-Borne Infections under Conditions of Mass Vaccination against Tick-Borne Viral Encephalitis (by the Example of a Megapolis)

Эпидемиология и вакцинопрофилактика, 2023
Relevance. The clinical aspects of tick­borne viral encephalitis (TBE) and Lyme borrelliosis (LB) as monoinfections are well known. At the same time, the issues of interaction of pathogens in tick­borne encephalitis – Lyme borrelliosis mixed infection ...
V. A. Mishchenko, I. V. Vyalykh, A. G. Sergeev, I. P. Bykov, M. G. Toporkova, V. I. Chalapa   +5 more
doaj   +1 more source