Results 31 to 40 of about 2,747,170 (398)

Blood-feeding, susceptibility to infection with Schmallenberg virus and phylogenetics of Culicoides (Diptera: Ceratopogonidae) from the United Kingdom

Parasites & Vectors, 2018
Background Culicoides biting midges (Diptera: Ceratopogonidae) are responsible for the biological transmission of internationally important arboviruses of livestock.
James Barber, Lara E. Harrup, Rhiannon Silk, Eva Veronesi, Simon Gubbins, Katarzyna Bachanek-Bankowska, Simon Carpenter   +6 more
doaj   +1 more source

Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]

, 2009
The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Ehrhardt, Anja, Müther, Nadine, Noske, Nadja   +2 more
core   +4 more sources

Clinical and Epidemiological Features of Actual Tick-Borne Infections under Conditions of Mass Vaccination against Tick-Borne Viral Encephalitis (by the Example of a Megapolis)

Эпидемиология и вакцинопрофилактика, 2023
Relevance. The clinical aspects of tick­borne viral encephalitis (TBE) and Lyme borrelliosis (LB) as monoinfections are well known. At the same time, the issues of interaction of pathogens in tick­borne encephalitis – Lyme borrelliosis mixed infection ...
V. A. Mishchenko, I. V. Vyalykh, A. G. Sergeev, I. P. Bykov, M. G. Toporkova, V. I. Chalapa   +5 more
doaj   +1 more source

Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters

Gene Therapy, 2020
Adeno-associated viral vectors are widely used as vehicles for gene transfer to the nervous system. The promoter and viral vector serotype are two key factors that determine the expression dynamics of the transgene.
Bart Nieuwenhuis, Barbara Haenzi, Sam Hilton, Alejandro Carnicer-Lombarte, B. Hobo, J. Verhaagen, J. Fawcett   +6 more
semanticscholar   +1 more source

Progress in the use of adeno-associated viral vectors for gene therapy [PDF]

, 2004
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Braun-Falco, M., Buning, H., Hallek, M.
core   +1 more source

Assembly and functional analysis of an S/MAR based episome with the cystic fibrosis transmembrane conductance regulator gene [PDF]

, 2018
Improving the efficacy of gene therapy vectors is still an important goal toward the development of safe and efficient gene therapy treatments. S/MAR (scaffold/matrix attached region)-based vectors are maintained extra-chromosomally in numerous cell ...
Ascenzioni, Fiorentina, Castellani, Stefano, Cavinato, Luca, Cimino, Giuseppe, Conese, Massimo, De Rocco, Davide, Guarnieri, Simone, Mariggiò, Maria A., Morini, Elena, Pompili, Barbara, Porto, Paola Del   +10 more
core   +6 more sources

Dual monoclonal antibody-based sandwich ELISA for detection of in vitro packaged Ebola virus

Diagnostic Pathology, 2018
Background Rapid transmission and high mortality of Ebola virus disease (EVD) highlight a urgent need of large scale, convenient and effective measure for Ebola virus screening. Application of monoclonal antibodies (mAbs) are crucial for establishment of
Junjie Zai, Kai Yi, Lilan Xie, Jiping Zhu, Xiaoting Feng, Yaoming Li   +5 more
doaj   +1 more source

Therapeutic modulation of gene expression in the disease state: Treatment strategies and approaches for the development of next-generation of the epigenetic drugs

Frontiers in Bioengineering and Biotechnology, 2022
Epigenetic dysregulation is an important determinant of many pathological conditions and diseases. Designer molecules that can specifically target endogenous DNA sequences provide a means to therapeutically modulate gene function.
Joseph Rittiner, Joseph Rittiner, Joseph Rittiner, Mohanapriya Cumaran, Mohanapriya Cumaran, Mohanapriya Cumaran, Sahil Malhotra, Sahil Malhotra, Sahil Malhotra, Boris Kantor, Boris Kantor, Boris Kantor   +11 more
doaj   +1 more source

A comparison of commercial light-emitting diode baited suction traps for surveillance of Culicoides in northern Europe

Parasites & Vectors, 2015
Background The response of Culicoides biting midges (Diptera: Ceratopogonidae) to artificial light sources has led to the use of light-suction traps in surveillance programmes.
Andrew Hope, Simon Gubbins, Christopher Sanders, Eric Denison, James Barber, Francesca Stubbins, Matthew Baylis, Simon Carpenter   +7 more
doaj   +1 more source

Pan-European Chikungunya surveillance: Designing risk stratified surveillance zones [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Tilston et alThe first documented transmission of Chikungunya within Europe took place in Italy during the summer of 2007.
Skelly, C, Tilston, N, Weinstein, P
core   +4 more sources