Results 31 to 40 of about 2,924,139 (391)
Vaccines, 2021 Viral vectors and viral vaccines are invaluable tools in prevention and treatment of diseases. Many infectious diseases are controlled using vaccines designed from subunits or whole viral structures, whereas other genetic diseases and cancers are being ...
Aline Do Minh, A. Kamen
semanticscholar +1 more source
Assembly and functional analysis of an S/MAR based episome with the cystic fibrosis transmembrane conductance regulator gene [PDF]
, 2018 Improving the efficacy of gene therapy vectors is still an important goal toward the development of safe and efficient gene therapy treatments. S/MAR (scaffold/matrix attached region)-based vectors are maintained extra-chromosomally in numerous cell ...
Ascenzioni, Fiorentina +10 more
core +7 more sources
Improved functionality and potency of next generation BinMLV viral vectors toward safer gene therapy
Molecular Therapy: Methods & Clinical Development, 2021 To develop safer retroviral murine leukemia virus (MLV)-based vectors, we previously mutated and re-engineered the MLV integrase: the W390A mutation abolished the interaction with its cellular tethering factors, BET proteins, and a retargeting peptide ...
Dominique Van Looveren +4 more
doaj +1 more source
Parasites & Vectors, 2018 Background Culicoides biting midges (Diptera: Ceratopogonidae) are responsible for the biological transmission of internationally important arboviruses of livestock.
James Barber +6 more
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An Improved Protocol for the Production of Lentiviral Vectors
STAR Protocols, 2020 Summary: Lentiviral vectors are an ideal gene-delivery system for large gene-editing tools, such as the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 system, due to their high packaging capacity and broad tropism.
Logan Y. Brown, Wendy Dong, Boris Kantor
doaj +1 more source
Progress in the use of adeno-associated viral vectors for gene therapy [PDF]
, 2004 The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Braun-Falco, M., Buning, H., Hallek, M.
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Applied biosafety : journal of the American Biological Safety Association, 2020 Introduction: National Institutes of Health (NIH) defines gene therapy as an experimental technique that uses genes to treat or prevent disease. Although gene therapy is a promising treatment option for a number of diseases (including inherited disorders,
Sumit Ghosh +3 more
semanticscholar +1 more source
Frontiers in Molecular Biosciences, 2021 Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, arose at the end of 2019 as a zoonotic virus, which is the causative agent of the novel coronavirus outbreak COVID-19. Without any clear indications of abatement, the disease has become a major
Rajashri Bezbaruah +7 more
semanticscholar +1 more source
Эпидемиология и вакцинопрофилактика, 2023 Relevance. The clinical aspects of tickborne viral encephalitis (TBE) and Lyme borrelliosis (LB) as monoinfections are well known. At the same time, the issues of interaction of pathogens in tickborne encephalitis – Lyme borrelliosis mixed infection ...
V. A. Mishchenko +5 more
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Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy. [PDF]
, 2017 Gene therapy by engineering patient's own blood cells to confer HIV resistance can potentially lead to a functional cure for AIDS. Toward this goal, we have previously developed an anti-HIV lentivirus vector that deploys a combination of shRNA, ribozyme ...
Castanotto, Daniela +4 more
core +1 more source