Results 31 to 40 of about 285,022 (264)

Launching the Leadership Academy

open access: yesVirginia Libraries, 2011
In April 2010, the Virginia Library Association (VLA) launched the Virginia Library Leadership Academy (VALLA), the first-ever leadership development training program of its kind for staff in Virginia libraries.
Elizabeth Hensley
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Virginia Institute of Genealogy Research

open access: yesVirginia Libraries, 2002
An innovative partnership between the Virginia Library Association and the Virginia Genealogical Society made a scholarship available for a VLA member to attend the annual Virginia Institute of Genealogical Research this past August.
Linda Derrer
doaj   +1 more source

Two Novel Energy Crops: Sida hermaphrodita (L.) Rusby and Silphium perfoliatum L.—State of Knowledge

open access: yesAgronomy, 2020
Current global temperature increases resulting from human activity threaten many ecosystems and societies, and have led to international and national policy commitments that aim to reduce greenhouse gas emissions.
Laura Cumplido-Marin   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

To the Lighthouse:

open access: yesCrossings, 2017
The study, diverging from current critical discourse on Virginia Woolf as eccentric author, sets out expressly to look at Woolf as enigmatic text. In so doing, it explores largely untapped Woolf terrain.
Adrian A. Husain
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Natural Resources of Virginia and West Virginia [PDF]

open access: yesScientific American, 1892
n ...
openaire   +1 more source

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