Results 41 to 50 of about 285,022 (264)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A Turning Point for Richmond: The Virginia Historical Society's Civil War Exhibition
Southern Spaces, 2011 William G. Thomas III reviews the Virginia Historial Society's exhibit, "An American Turning Point: The Civil War in Virginia."
William G. Thomas III
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Virginia Library Leadership Academy 2014
Virginia Libraries, 2013 The Leadership Development Forum of the Virginia Library Association is sponsoring the 3rd Virginia Library Leadership Academy (VALLA), facilitated by nationally recognized speaker, Dr.
Teresa Doherty
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Mapping the Desegregation of Education in Virginia: Where Are the Records?
Virginia Libraries, 2009 A century from now, will desegregation in Virginia be a forgotten story? If we don’t do a better job of saving our records, it could be. Currently, few records of school desegregation in Virginia are publicly available.
Sonia Yaco, Tonia Graves
doaj +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
In the Digital Age, Preserving the Print of the Past
Virginia Libraries, 2013 For the past 20 years, a project at the Library of Virginia in Richmond has been laboring to find and preserve a form of media communication that has been waning: Virginia’s newspapers.
John Connolly
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Energies, 2019 Hydrodynamic cavitation was recently applied as a biomass pretreatment method. Most of the studies which used hydrodynamic cavitation were applied to pretreated sugarcane bagasse or reed.
Marcin Zieliński +5 more
doaj +1 more source