Results 111 to 120 of about 111,761 (236)

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source

Virion factors that target Daxx to overcome intrinsic immunity.

, 2013
International audiencePML nuclear bodies and their associated functions are part of an intrinsic cellular mechanism aimed at maintaining transcriptional control over viral gene expression and preventing replication of invading viruses.
Wodrich, Harald, Schreiner, Sabrina
core   +1 more source

Enhanced Recombinant Adeno‐Associated Virus (rAAV) Biomanufacturing: Design of Experiment (DOE) Enabled Transfection Optimization for Maximum Full Capsid Yield and Robust Scale‐Up

Biotechnology Journal, Volume 21, Issue 6, June 2026.
Graphical Abstract and Lay Summary The graphic presents our 2‐stage DOE approach used for transfection optimization to produce rAAV5 consisting of a screening DOE to identify significant factors, followed by an RSD for optimization. Optimal conditions were scaled up from 6‐well plates to a 50L WAVE reactor resulting in > 60% full capsids at scale ...
Alexandra Bogdanovic, Nicholas Donohue, Brian Glennon, Susan Mc Donnell, Jessica Whelan   +4 more
wiley   +1 more source

A Mechanistic Model of rAAV Production in Synthetic Cell Lines

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1684-1694, June 2026.
ABSTRACT The recombinant adeno‐associated virus (rAAV) is a widely used vector for gene therapy. Its manufacturing faces significant challenges in producing the large quantities of vectors needed for clinical applications and reducing empty particles.
Prahalad Srinivasan, Han‐Jung Kuo, Yu‐Chieh Lin, Yen‐An Lu, Wei‐Shou Hu, Qi Zhang   +5 more
wiley   +1 more source

Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity. [PDF]

Nat Commun
Yao H, Song Y, Huang Q, Zhu M, Liang J, Zhang Z, Zhang X, Dong D, Shi D, Wu Z, Lu X, Wu H, Chen Y, Li S.   +13 more
europepmc   +1 more source

The spread of non‐native species

Biological Reviews, Volume 101, Issue 3, Page 1197-1234, June 2026.
ABSTRACT The global redistribution of species through human agency is one of the defining ecological signatures of the Anthropocene, with biological invasions reshaping biodiversity patterns, ecosystem processes and services, and species interactions globally.
Phillip J. Haubrock, Ali Serhan Tarkan, Irene Martín‐Forés, Stelios Katsanevakis, Ronaldo Sousa, Ismael Soto, Andy J. Green, Antonín Kouba, Teun Everts, Victoria Dominguez Almela, Nadège Belouard, Cang Hui, Jamie Bojko, Victor Deklerck, Margaux Boeraeve, Franz Essl, J. Robert Britton   +16 more
wiley   +1 more source

Immunomagnetic Sample Preparation Targeting Host- and Viral-Derived Antigens for HIV-1 Isolation from Limited Plasma Volumes. [PDF]

Anal Chem
Gulati GK, Panpradist N, Lutz BR, Lai JJ.   +3 more
europepmc   +1 more source

The raft-promoting property of virion-associated cholesterol, but not the presence of virion-associated brij 98 rafts, is a determinant of human immunodeficiency virus type 1 infectivity

, 2004
Lipid rafts are enriched in cholesterol and sphingomyelin and are isolated on the basis of insolubility in detergents, such as Brij 98 and Triton X-100. Recent work by Holm et al.
S Crowe (13428231), K Gaus (13678285), S Campbell (7641563), R Bittman (13681630), W Jessup (13726693), Johnson Mak (13082904)   +5 more
core  

Human Papillomavirus: Update in Bridging Basic Science to Clinical and Public Health Innovations

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Human papillomavirus (HPV), a non‐enveloped, double‐strand DNA viral pathogen, is intricately linked with the onset of various cancers, including cervical cancer and head and neck cancers. The present paper delves into HPV's ancient recognition and significant milestones such as the discovery of its role in oncogenesis and the development of ...
Fatemeh Beygnejad, Narges Eslami, Kaveh Gharaei Nejad, Atefeh Zamani Kermanshahi, Hossein Bannazadeh Baghi   +4 more
wiley   +1 more source

Elucidating the protein interaction network of one of the largest icosahedral capsids in the virosphere. [PDF]

EMBO J
Safi H, Schmitt A, Tollec A, Belmudes L, Colmant AMG, Poirot O, Santini S, Legendre M, Couté Y, Bisio H, Abergel C.   +10 more
europepmc   +1 more source