Results 141 to 150 of about 102,321 (242)

Structural Advances in Respiratory Syncytial Virus: Implications for Vaccine and Antiviral Development. [PDF]

Microorganisms
Huang X, Akıl C, Zhang P.
europepmc   +1 more source

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Viral evolution during primary infection in immunocompromised hosts. [PDF]

PLoS Comput Biol
Craig M, Deng X, McLeod DV.
europepmc   +1 more source

Bemnifosbuvir: An HCV NS5B Inhibitor With Multiple Modes of Action

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 552-562, August 2026.
Bemnifosbuvir (BEM) is a potent, pan‐genotypic inhibitor targeting the hepatitis C virus (HCV) NS5B polymerase. Its antiviral activity was evaluated in an ascending dose phase I clinical trial involving 30 patients treated once a day for 7 days. After treatment initiation, plasma HCV RNA declined in a biphasic manner with a mean reduction of 2.3 log10 ...
Carolin Zitzmann, Ruy M. Ribeiro, Aurélien Marc, Xiao‐Jian Zhou, Alan S. Perelson   +4 more
wiley   +1 more source

Exceeding expectations: factors contributing to the potency of human papillomavirus vaccines. [PDF]

Lancet Microbe
Schiller JT, Kines RC, Day PM, Çuburu N, Kreimer AR, Lowy DR.   +5 more
europepmc   +1 more source

SARS‐CoV‐2 Spike Peptides Trigger Nociceptive Responses Through Spinal TLR4 Pathways

European Journal of Pain, Volume 30, Issue 7, August 2026.
ABSTRACT Background Pain is a common neurological manifestation of COVID‐19, yet the mechanisms by which SARS‐CoV‐2 spike protein fragments contribute to nociceptive processing remain poorly understood. We investigated whether spike‐derived peptides directly activate spinal neuroimmune pathways involved in pain signalling.
Bruno Eduardo Silva, Rayner Ribeiro Cardoso, Lívia Maria Ribeiro Rosário, João Paulo Prado, Rafaela Silva dos Santos, Flávio Protasio Veras, Mylena de Souza, Eduardo Maffud Cilli, Danilo Olivier, Marco Antonio de Andrade Belo, Ives Charlie‐Silva, Ester Siqueira Caixeta, Angel Roberto Barchuk, Albená Nunes‐Silva, Thiago Roberto Lima Romero, Giovane Galdino   +15 more
wiley   +1 more source

ICTV Virus Taxonomy Profile: <i>Rhabdoviridae</i> 2026. [PDF]

J Gen Virol
Walker PJ, Bejerman N, Blasdell KR, Debat H, Dietzgen RG, Fooks AR, Freitas-Astúa J, Garver K, Kondo H, Ramos-González PL, Shi M, Tesh RB, Tordo N, Vasilakis N, Whitfield AE.   +14 more
europepmc   +1 more source

Clinical‐Stage Nanatinostat Triggers Productive Epstein‐Barr Virus Lytic Replication

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT A phase 1b/2 study of the all‐oral “kick‐and‐kill” combo nanatinostat + valganciclovir (nana‐val) showed a ~40% overall response rate in patients with relapsed/refractory Epstein‐Barr virus (EBV)‐associated lymphomas. Despite the promising results in these difficult‐to‐treat cancers, there is little known about the effects of nanatinostat on ...
Ibukun A. Akinyemi, Travis M. Zeigler, Griffin H. Willman, Devshree Patel, Ayman El‐Guindy, Michael T. McIntosh, Sumita Bhaduri‐McIntosh   +6 more
wiley   +1 more source

Virus-encoded metabolism may support environmental stress adaptation of microbial hosts in an estuarine hypoxic zone. [PDF]

Front Microbiol
Sun M, Lei Z, Li B, Gao SH, Fan L.
europepmc   +1 more source

SNHG15 Positively Regulates Influenza Virus Infection Through Its Association With miR‐153 and RABL2A

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Influenza viruses cause seasonal epidemics, and current vaccines do not fully protect against them. This study focuses on long non‐coding RNAs (lncRNAs), which are RNA molecules that do not code for proteins but play crucial roles in various biological processes. We identified 17 lncRNAs altered by the influenza virus.
Samuel Pushparaj, Kishore Vaddadi, Chaoqun Huang, Yurong Liang, Dao Xu, Gayan Bamunuarachchi, Prince Jhandai, Keerthana Santhosh, Elizabeth Varghese, Lin Liu   +9 more
wiley   +1 more source