Results 251 to 260 of about 45,169 (292)

Tackling virological failure in HIV-infected children living in Africa

Expert Review of Anti-infective Therapy, 2015
Drug resistance in HIV-infected children is one of the main contributors to antiretroviral treatment (ART) failure, especially in developing countries. Sub-Saharan Africa has the largest burden of pediatric HIV infection in the world. Herein, we systematically review the current status of ART failure in HIV-infected African children.
Mohammad-Ali, Jenabian, Cecilia T, Costiniuk, Ralph-Sydney, Mboumba Bouassa, Linda, Chapdeleine Mekue Mouafo, Thomas V, Brogan, Laurent, Bélec   +5 more
openaire   +2 more sources

PROTEASE INHIBITOR RESISTANCE IN SOUTH AFRICAN CHILDREN WITH VIROLOGIC FAILURE

Pediatric Infectious Disease Journal, 2009
In South Africa, first-line antiretroviral therapy for children younger than 3 years of age combines a protease inhibitor (PI) with 2 nucleoside reverse transcription inhibitors. In our study, some pediatric patients received ritonavir (RTV) as single PI (RTV-sPI) and others ritonavir-boosted lopinavir (LPV/r), which has a higher resistance barrier. We
Van Zyl G.U., Van Der Merwe L., Claassen M., Cotton M.F., Rabie H., Prozesky H.W., Preiser W.   +6 more
openaire   +3 more sources

Cerebrospinal fluid response to structured treatment interruption after virological failure

AIDS, 2001
Structured antiretroviral treatment interruption (STI) has been advocated as a therapeutic strategy for HIV-1 infection. We report initial observations of cerebrospinal fluid (CSF) HIV-1 infection in five patients undergoing serial lumbar punctures (LPs) during STI undertaken following virological failure.In this prospective observational study we ...
R W, Price, E E, Paxinos, R M, Grant, B, Drews, A, Nilsson, R, Hoh, N S, Hellmann, C J, Petropoulos, S G, Deeks   +8 more
openaire   +2 more sources

Virological patterns of HCV patients with failure to interferon‐free regimens

Journal of Medical Virology, 2018
The study characterized the virological patterns and the resistance‐associated substitutions (RASs) in patients with failure to IFN‐free regimens enrolled in the real‐life setting. All 87 consecutive HCV patients with failed IFN‐free regimens, observed at the laboratory of the University of Campania, were enrolled.
Starace M, Minichini C, De Pascalis S, Macera M, Occhiello L, Messina V, Sangiovanni V, Adinolfi LE, Claar E, Precone D, Stornaiuolo G, Stanzione M, Ascione T, Caroprese M, Zampino R, Parrilli G, Gentile I, Brancaccio G, Iovinella V, Martini S, Masarone M, Fontanella L, Masiello A, Sagnelli E, Punzi R, Salomone Megna A, Santoro R, Gaeta GB, Coppola N., Stornaiuolo G, Zampino R. Parrilli G, Masarone M.   +31 more
openaire   +5 more sources

Does an Increase in Nevirapine Plasma Levels Cause Complete Virologic Suppression in Patients Experiencing Early Virologic Failure?

HIV Clinical Trials, 2002
Patients on two nucleoside analogs plus nevirapine (NVP) who show low-level plasma HIV RNA might have insufficient NVP plasma levels and therefore might benefit from an increase in NVP dosing.The dose of NVP was increased from 400 mg/day to 600 mg/day in 25 participants taking NVP-containing triple combinations for at least 3 months and experiencing a ...
Daniel González, de Requena, Marina, Núñez, Oscar, Gallego, Inmaculada, Jiménez-Nácher, Juan, González-Lahoz, Vincent, Soriano   +5 more
openaire   +2 more sources

Virologic Failure of High-Dose Raltegravir With Concomitant Rifampin

Infectious Diseases in Clinical Practice, 2017
Abstract Treating mycobacterial infections and HIV concurrently typically presents difficulties due to drug-to-drug interactions between rifampin and many antiretrovirals. We present a case of raltegravir failure during concomitant rifampin use, despite documented administration of recommended increased dose of raltegravir.
Misty M. Miller, Karen K. Kinney, Michelle D. Liedtke   +2 more
openaire   +1 more source

Continue Antiretroviral Therapy during Virologic Failure?

Clinical Infectious Diseases, 2002
Davey Smith, Joseph Wong
openaire   +1 more source

Management of patients with virologic and metabolic failure.

The AIDS reader, 2003
The greatest challenge faced by HIV-treating clinicians today is the management of virologic failure and metabolic complications of anti-HIV treatment. Resistance testing plays an essential role in selecting appropriate agents for salvage therapy. Too often, however, the choice of agents is limited by broad cross-resistance or toxicities, such as ...
openaire   +1 more source

Early virological failure with cabotegravir/rilpivirine

Journal of Antimicrobial Chemotherapy
L Bailón, S Sábato, J Coll, J R Santos, C Miranda, T Puig, A D´Avolio, R Paredes, J Moltó, E Negredo   +9 more
openaire   +4 more sources

Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study

Lancet, The, 2022
Clara Suñer, Andrés Antón, JOSE MIGUEL CABRERA GUARIN   +2 more
exaly