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Low-Level Viremia among Adults Living with HIV on Dolutegravir-Based First-Line Antiretroviral Therapy Is a Predictor of Virological Failure in Botswana. [PDF]

Viruses
Bareng OT, Moyo S, Mudanga M, Sebina K, Koofhethile CK, Choga WT, Moraka NO, Maruapula D, Gobe I, Motswaledi MS, Musonda R, Nkomo B, Ramaabya D, Chebani T, Makuruetsa P, Makhema J, Shapiro R, Lockman S, Gaseitsiwe S.   +18 more
europepmc   +1 more source

The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure [PDF]

Tropical Medicine and International Health, 2012
Objectives  To determine the improvement in positive predictive value of immunological failure criteria for identifying virological failure in HIV-infected children on antiretroviral therapy (ART) when a single targeted viral load measurement is ...
Karl-Günter Technau, Matthias Egger
exaly   +4 more sources

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Virologic Correlates of Adherence to Antiretroviral Medications and Therapeutic Failure

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2002
Adherence to antiretroviral therapy affects the pharmacokinetics of antiviral drugs and activates a cascade of events ultimately leading to therapeutic success or failure. An optimal adherence usually affords minimal rounds of virus replication and rare spontaneous mutations, which are unable to be fixed in the genome because of the competition of wild-
C. F. Perno, F. Ceccherini Silberstein, A. De Luca, A. Cozzi Lepri, C. Gori, A. Cingolani, M. C. Bellocchi, M. P. Trotta, P. Piano, F. Forbici, A. Scasso, V. Vullo, A. d’Arminio Monforte, A. Antinori, for the AdICoNA Study Group   +14 more
openaire   +8 more sources

Virological and immunological characteristics of HIV treatment failure

AIDS, 2000
Resistance to antiretroviral treatment is prevalent. There is limited knowledge of the determinants of disease evolution in subjects infected with multidrug-resistant HIV (MDR-HIV).Infectivity, replication, chemokine receptor usage, and env, gag, protease and reverse transcriptase sequence analysis was performed for MDR-HIV isolates from 14 HIV ...
Kaufmann D, Muñoz M, Bleiber G, Fleury S, Lotti B, Martinez R, Pichler W, Meylan P, Telenti A   +8 more
openaire   +3 more sources

Virologic suppression in treatment-experienced patients after virologic rebound or failure of therapy

Current Opinion in HIV and AIDS, 2011
To discuss factors related to virologic failure and review data from recent clinical trials evaluating re-suppression of viremia in extensively-treated HIV-infected patients with resistance.Factors associated with virologic failure can be related to the virus (e.g. resistance), the patient (e.g. adherence) or HIV therapy (e.g. availability) and must be
Rui, Sarmento-Castro, Carlos, Vasconcelos, Maria João, Aguas, Rui, Marques, Joaquim, Oliveira   +4 more
openaire   +2 more sources

Evaluation and management of early virological failure

Current Opinion in HIV and AIDS, 2006
To describe the causes, evaluation, and management of early virological failure in patients treated with their first antiretroviral regimen.Combination antiretroviral therapy predictably induces a rapid virological response, with the majority of patients achieving an undetectable HIV-RNA load by week 24.
openaire   +2 more sources

Early Virological Failure with a Combination of Tenofovir, Didanosine and Efavirenz

Antiviral Therapy, 2005
Objective To describe the occurrence of a high early virological failure (VF) rate and development of resistance mutations in antiretroviral-naive patients receiving tenofovir, didanosine and efavirenz.
Daniel, Podzamczer, Elena, Ferrer, Josep Maria, Gatell, Jordi, Niubo, David, Dalmau, Agathe, Leon, Hernando, Knobel, Carolina, Polo, Daniel, Iniguez, Isaac, Ruiz   +9 more
openaire   +2 more sources

Virological patterns of HCV patients with failure to interferon‐free regimens

Journal of Medical Virology, 2018
The study characterized the virological patterns and the resistance‐associated substitutions (RASs) in patients with failure to IFN‐free regimens enrolled in the real‐life setting. All 87 consecutive HCV patients with failed IFN‐free regimens, observed at the laboratory of the University of Campania, were enrolled.
Starace M, Minichini C, De Pascalis S, Macera M, Occhiello L, Messina V, Sangiovanni V, Adinolfi LE, Claar E, Precone D, Stornaiuolo G, Stanzione M, Ascione T, Caroprese M, Zampino R, Parrilli G, Gentile I, Brancaccio G, Iovinella V, Martini S, Masarone M, Fontanella L, Masiello A, Sagnelli E, Punzi R, Salomone Megna A, Santoro R, Gaeta GB, Coppola N., Stornaiuolo G, Zampino R. Parrilli G, Masarone M.   +31 more
openaire   +5 more sources