Results 231 to 240 of about 45,169 (292)

Real-world prevalence of integrase inhibitor resistance and virological failure since adoption as guideline-preferred therapy. [PDF]

Drugs Context
Januszka J, Drwiega E, Burgos R, Smith R, Badowski M.   +4 more
europepmc   +1 more source

Expertise is the new infrastructure

Journal of Microscopy, EarlyView.
Abstract Today's life science endeavours are complex and interconnected, and they face diverse challenges, such as budgetary insecurity and the reproducibility crisis. As a result, core facilities have become vital in research institutes, transitioning from mere conveniences to essential components that ensure instrument access.
Pablo Hernandez‐Varas, Chiara Rossi, Erin M. Tranfield, Baubak Bajoghli, Clara Prats, Winnok H. De Vos, Sebastian Munck   +6 more
wiley   +1 more source

Hyperspectral tomographic diffractive microscopy: Development and applications

Journal of Microscopy, EarlyView.
Abstract Tomographic Diffractive Microscopy (TDM) provides label‐free three‐dimensional imaging of transparent samples with resolution surpassing confocal limits. At IRIMAS, successive instrumental developments since 2009 have enhanced TDM capabilities through transmission, reflection, isotropic, polarisation‐sensitive, and dual‐view configurations ...
Leonardo Pestana Legori, Carlos Alberto Chacón Ávila, Matthieu Debailleul, Nicolas Verrier, Olivier Haeberlé   +4 more
wiley   +1 more source

Factors Affecting Virological Failure in Children Receiving First-Line Antiretroviral Therapy in Ethiopian Healthcare Facilities: A Retrospective Analysis. [PDF]

Pediatric Health Med Ther
Desalegn M, Shitemaw T, Tesfaye M, Getahun GK.   +3 more
europepmc   +1 more source

Representing, Re‐presenting, or Producing the Past? Memory Work amongst Museum Employees

Journal of Management Studies, EarlyView.
Abstract Though it is widely understood that the past can be an important resource for organizations, less is known about the micro‐level skills and choices that help to materialize different representations of the past. We understand these micro‐level skills and choices as a practice: ‘memory work’ – a banner term gathering various activities that ...
Jeremy Aroles, Kevin Morrell, Edward Granter, Yin Liang   +3 more
wiley   +1 more source

Prevalence of Drug Resistance Associated Substitutions in Persons With Chronic Hepatitis C Infection and Virological Failure Following Initial or Re-treatment With Pan-genotypic Direct-Acting Antivirals: A Systematic Review and Meta-analysis. [PDF]

Clin Infect Dis
Inzaule S, Easterbrook P, Latona A, Ford NP, Irving W, Matthews PC, Vitoria M, Duncombe C, Giron A, McCluskey S, Lesi O, Tchamgoue S, Halford R, Adda D, Thomson E, Dusheiko G, Jordan MR.   +16 more
europepmc   +1 more source

Redundant and Flexible Electron Transfer Pathways Underlie MsrPQ‐Mediated Repair of Oxidized Periplasmic Proteins

Molecular Microbiology, EarlyView.
This study investigates in vivo the role of the flavin reductase Fre as an electron supplier to the periplasmic methionine sulfoxide reductase system MsrPQ. ABSTRACT The MsrPQ system is essential for the repair of oxidized methionine residues in periplasmic proteins, ensuring bacterial resistance to oxidative stress and envelope integrity.
Laurent Loiseau, Benjamin Ezraty
wiley   +1 more source

Investigating rates and predictors of viral blips, low-level viraemia and virological failure in the Australian HIV observational database. [PDF]

Trop Med Int Health
Han WM, Broom J, Bopage R, Templeton DJ, Edmiston N, Petoumenos K, Australian HIV Observational Database.   +6 more
europepmc   +1 more source

PLP Homeostasis Protein Is Required for Efficient Maturation of Aromatic Amino Acid Aminotransferase in Salmonella enterica

Molecular Microbiology, EarlyView.
Cellular pool of aromatic amino acid aminotransferase proteins represented as holo‐ or apo‐ enzymes, reflecting presence or absence of associated PLP. Status of PLPHP is implicated in determining the ratio of holo‐ and apo‐TyrB. ABSTRACT Pyridoxal 5′‐phosphate (PLP) is an essential cofactor required for metabolic functions including amino acid ...
Brandi A. Buckner, Diana M. Downs
wiley   +1 more source

In Salmonella Typhimurium, YiiD Modulates cAMP Levels in Lag Phase During Growth on Succinate

Molecular Microbiology, EarlyView.
The YiiD enzyme, found by others to perform a redundant role in fatty acid biosynthesis, is found to be unexpectedly required for the early increase in cAMP in lag phase during growth on succinate. This intriguing finding suggests a mechanistic link may exist between fatty acid biosynthesis and catabolite repression. ABSTRACT In Salmonella Typhimurium (
John A. Ciemniecki, Jessica L. Will, Jorge C. Escalante‐Semerena   +2 more
wiley   +1 more source