Results 101 to 110 of about 384,922 (349)

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

The Frontier of Entomo-Virology: Applications and Tools for Virus and Vector Surveillance

Pathogens
The term ‘entomo-virology’ arose because of the confluence of entomology and virology, focused on deepening the knowledge about the interactions between vectors and viruses and the aspects that involve hosts and the environment.
Poliana da Silva Lemos, Mayron Mielly Morais Pacheco, Bruna Laís Sena do Nascimento, Mônica Silva Coelho, Luciano Chaves Franco Filho, Daniel Damous Dias, Leonardo Sena, Sandro Patroca da Silva, Maria Anice Mureb Sallum   +8 more
doaj   +1 more source

Single-cell virology: on-chip investigation of viral infection dynamics

Cell Reports, 2017
We have developed a high-throughput, microfluidics-based platform to perform kinetic analysis of viral infections in individual cells. We have analyzed thousands of individual poliovirus infections while varying experimental parameters, including ...
Feng Guo, Sixing Li, M. Caglar, Zhangming Mao, Wu Liu, A. Woodman, Jamie J. Arnold, C. Wilke, T. Huang, C. Cameron   +9 more
semanticscholar   +1 more source

Induction of Antiviral Immune Response through Recognition of the Repeating Subunit Pattern of Viral Capsids Is Toll-Like Receptor 2 Dependent

mBio, 2017
Although viruses and viral capsids induce rapid immune responses, little is known about viral pathogen-associated molecular patterns (PAMPs) that are exhibited on their surface.
Kelly M. Shepardson, Benjamin Schwarz, Kyle Larson, Rachelle V. Morton, John Avera, Kimberly McCoy, Alayna Caffrey, Ann Harmsen, Trevor Douglas, Agnieszka Rynda-Apple   +9 more
doaj   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

The 23rd Annual Meeting of the Rocky Mountain Virology Association

Located 50 miles west of Fort Collins, Colorado, Colorado State University’s Mountain Campus in Pingree Park hosted the 23rd annual Rocky Mountain Virology Association meeting in 2023 with 116 participants.
Ali L. Brehm, Samantha M. Pinto, Oshani C. Ratnayake, Molly E. Ring, Tillie J. Dunham, Kaitlynn A. Williams, Joel Rovnak, Kathryn L. Coffin, Rushika Perera   +8 more
core   +1 more source

Amplification chemistries in clinical virology

Journal of Clinical Virology, 2019
Molecular diagnostic methods have evolved and matured considerably over the last several decades and are constantly being evaluated and adopted by clinical laboratories for the identification of infectious pathogens.
S. Dunbar, Shubhagata Das
semanticscholar   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Placental crises: disruptive selection and maternal under‐investment as the foundations of mammalian placental evolution and dysfunction

Biological Reviews, EarlyView.
ABSTRACT Among the vertebrates, mammals are notable for the dominance of live birth and placental nutrition. The structural diversity of the mammalian placenta is remarkable, despite sharing a single common ancestor and conserved physiological functions.
Davis Laundon, Neil J. Gostling, Ian G. Reddin, Bram G. Sengers, Pascale Chavatte‐Palmer, Rohan M. Lewis   +5 more
wiley   +1 more source

Spatial metrics in fire ecology: seeking consistency amidst complexity

Biological Reviews, EarlyView.
ABSTRACT Technological advances, including remote sensing, have led to a proliferation of metrics used in ecological studies to examine spatial patterns of fire regimes and their ecological effects. Researchers can use many different metrics to analyse spatial variation in both fire events and resulting fire regimes, including fire size, shape ...
Alexander R. Carey, Geoffrey J. Cary, Teigan Cremona, Hugh F. Davies, Brett P. Murphy, Sam C. Banks   +5 more
wiley   +1 more source