Results 121 to 130 of about 325,358 (303)
Virology Journal -- new OA journal on BMC
, 2004 Virology Journal is ready to debut at BioMed Central. Virology Journal is an Open Access journal emphasizing rapid communication of high quality original research in human, animal, plant, insect, bacterial and fungal viruses.
Peter Suber
core +1 more source
Biotechnology Progress, EarlyView.Abstract Traditional off‐line analysis methods to quantify residual metabolite concentrations in a drug substance fermentation process consume valuable time, require costly resources, and demand potentially hazardous manual operations when working with pathogenic biological organisms.
Griffin P. Thomas +7 more
wiley +1 more source
Biotechnology Progress, EarlyView.Abstract In biopharmaceutical manufacturing, protein aggregation is a critical quality attribute, necessitating rapid and reliable analytical strategies during downstream processes like anion‐exchange chromatography (AEX). While Raman spectroscopy enables continuous monitoring of protein secondary structure, standard data‐driven regression models ...
Jakob Heyer‐Müller +4 more
wiley +1 more source
Navigating Virology’s Frontiers in Africa: Global Virus Network 2024 Durban Meeting
The Global Virus Network (GVN) is a voluntary consortium of virology laboratories and affiliated scientists that seek to prevent and control global viral threats.
Rubeshan Perumal +3 more
core +1 more source
Scalable catalyst production process for oleate hydratase whole‐cell biocatalysis
Biotechnology Progress, EarlyView.This study establishes a scalable lactose‐induced fed‐batch fermentation for an Escherichia coli whole‐cell biocatalyst containing an oleate hydratase. Operation at a higher growth rate markedly increased biomass yields while maintaining catalyst activity and was demonstrated at 150 L scale.
Rebekka Horstmann +6 more
wiley +1 more source
Biotechnology Progress, EarlyView.Abstract High performance countercurrent membrane purification (HPCMP) has emerged as a promising diffusive separation strategy for the purification of recombinant proteins and monoclonal antibodies (mAbs). However, prior studies employed dialysis membranes, which are designed for diffusive separations but have not been validated for biopharmaceutical ...
Aylin Mohammadzadehmarandi +8 more
wiley +1 more source
Biotechnology Progress, EarlyView.Abstract Development of therapeutic bispecific antibodies (BsAbs) poses significant manufacturability challenges associated with correct chain pairing and an increased diversity of impurities. Here we address this with a product quality assessment during cell line development (CLD), forgoing the need for genetic characterization during cell line ...
Molly Robinson +7 more
wiley +1 more source
Demonstration of nanofiltration‐based virus safety for AAV manufacturing using model viruses
Biotechnology Progress, EarlyView.Abstract Virus safety for biopharmaceutical products has been a well‐established concern for several decades. While various virus reduction steps have been identified and implemented for traditional plasma‐derived and monoclonal antibody products, there are various challenges to achieving the same virus safety in emerging gene therapy products.
Brian Buesing +2 more
wiley +1 more source