Results 121 to 130 of about 332,784 (298)
Biotechnology Progress, EarlyView.Abstract Sterile filtration represents the final critical step in biomanufacturing, where a sterilizing‐grade membrane filter removes microbial contamination from the drug product — making filter integrity verification essential. While bubble point and gas–liquid diffusion tests are established non‐destructive methods for hydrophilic membranes ...
Anand Alembath, Joseph Hersey
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyMpox (Monkeypox) is a highly contagious viral disease that can be transmitted from animal-to-human or human-to-human through intimate contact, Mpox is caused by the monkeypox virus (MPXV), which is an enveloped double-stranded DNA that belongs to the ...
Almonther Abdullah Hershan
doaj +1 more source
Biotechnology Progress, EarlyView.SIM‐CaliRam combines simulation‐informed references and biomass‐augmented features for in‐line Raman calibration under sparse labels and biomass‐induced spectral confounding. Run‐wise calibration and validation enable prediction of biomass, glucose, ammonium, and phosphate on an unseen S. cerevisiae fed‐batch fermentation.
Terrance Wilms, Steffi Knorn
wiley +1 more source
Biotechnology Progress, EarlyView.Flocculation using cationic polymers leads to the creation of large floc complexes. Negative charged species like cells, cell debris, and negatively charged host cell impurities like host cell DNA and host cell proteins are trapped within the complex while the positively charged monoclonal antibody stays in solution.
Anna‐Carina Frank +9 more
wiley +1 more source
A review of the inhibitory waste metabolites produced during mAb biomanufacturing
Biotechnology Progress, EarlyView.The review highlights inhibitory metabolites in CHO cell cultures, such as lactate, ammonia, isobutyrate, and isovalerate, impacting growth and productivity. Identification methods include LC/MS‐based metabolomics, while control strategies involve media optimization, genetic engineering, and process adjustments (pH, temperature).
Zhao Wang +5 more
wiley +1 more source
, 2014 Plant virology in AfricaDr Mawuena Y. Dieudonne Gumedzoe of the University of Benin also writes in support of The future of plant virology in Africa. 'Virologists have to make practical proposals to policy makers. It is a good idea that an African..
Technical Centre for Agricultural and Rural Cooperation
core +1 more source
Virology, immunology and secondary endpoints over all follow-up.
, 2018 Virology, immunology and secondary endpoints over all follow-up.
Patricia M. Flynn (705085) +25 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Bemnifosbuvir (BEM) and ruzasvir (RZR) are pan‐genotypic HCV polymerase (NS5B) and NS5A inhibitors, respectively. In a single‐arm study (NCT05904470), 215 treatment‐naïve, adherent participants with chronic HCV (with or without cirrhosis) received BEM 550 mg QD plus RZR 180 mg QD for 8 weeks.
Carolin Zitzmann +4 more
wiley +1 more source
Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access
Clinical Pharmacology &Therapeutics, EarlyView.Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Influenza viruses cause substantial global morbidity and mortality. Molnupiravir, an orally administered prodrug of β‐D‐N4‐hydroxycytidine, has broad activity against RNA viruses, including influenza. A phase 2a, randomized, two‐part human challenge trial in healthy adults (NCT05818124) was conducted to evaluate molnupiravir for influenza infection. In
Jesse Nussbaum +11 more
wiley +1 more source