Results 141 to 150 of about 325,358 (303)

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Correction: Full genome sequencing, evolutionary dynamics, and pathogenicity evaluation of chicken infectious anemia virus with emphasis on Upper Egypt reveals genetic variability linked to vaccinal strains. [PDF]

Virol J
Shosha EAE, Eldaghayes I, Zanaty AM, Gamaleldin MA, Mohamed MM, Maha ANG, Ahmed DAA.   +6 more
europepmc   +1 more source

Multiscale Modeling of an 8‐Week Combination Regimen of Bemnifosbuvir and Ruzasvir in Patients with Chronic Hepatitis C Virus Infection

Clinical Pharmacology &Therapeutics, EarlyView.
Bemnifosbuvir (BEM) and ruzasvir (RZR) are pan‐genotypic HCV polymerase (NS5B) and NS5A inhibitors, respectively. In a single‐arm study (NCT05904470), 215 treatment‐naïve, adherent participants with chronic HCV (with or without cirrhosis) received BEM 550 mg QD plus RZR 180 mg QD for 8 weeks.
Carolin Zitzmann, Ruy M. Ribeiro, Aurelien Marc, Xiao‐Jian Zhou, Alan S. Perelson   +4 more
wiley   +1 more source

The coding-complete genome sequence of Arabidopsis latent virus 1 from Iraq. [PDF]

Microbiol Resour Announc
Hadi AA, Mohammadali MT, Al-Zurfi SM, Lahuf AA.   +3 more
europepmc   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Complete coding sequence of influenza A virus subtype H1N3 from guinea fowl in Republic of Serbia. [PDF]

Microbiol Resour Announc
Vidanović D, Maletić J, Šekler M, Tešović B, Vasković N, Dmitrić M, Đurđević B, Giussani E, Zamperin G.   +8 more
europepmc   +1 more source

Virology

, 1979
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Offprint: Virology (1979)Title from captionIncludes ...

core  

Cytoflow: User‐Friendly Python Software for Computational Flow Cytometry

Cytometry Part A, EarlyView.
ABSTRACT Modern flow cytometry experiments routinely measure 18 or more fluorescent markers across many samples, patients, and tissues. As these experiments' complexity increases, manual gating becomes unacceptably inefficient and can introduce operator‐to‐operator variation. Computational cytometry algorithms such as unsupervised clustering, automated
Leah Teague
wiley   +1 more source

Coding-complete genome sequence of grapevine leafroll-associated virus 13 from grapevine in California. [PDF]

Microbiol Resour Announc
Abou Kubaa R, Erickson TM, Li H, Stevens KA, Al Rwahnih M.   +4 more
europepmc   +1 more source

High‐Dimensional Spectral Flow Cytometry Panel for Immunophenotypic Characterization of Fixed Whole Blood Samples

Cytometry Part A, EarlyView.
ABSTRACT Peripheral blood mononuclear cells (PBMCs) are commonly used for immune profiling in clinical research, but their isolation and cryopreservation present logistical challenges, particularly in settings with limited access to research facilities. To address this, we implemented a whole blood fixation protocol to preserve surface protein epitopes
Vaishnavi Parthasarathy, Alexander T. Heubeck, Tyanna Stuckey, Veronica Hernandez, Blessing Musgrove, Maia M. Bennett‐Boehm, Troy Torgerson, Peter Skene, Julian Reading   +8 more
wiley   +1 more source