Results 141 to 150 of about 345,407 (349)

Optimizing clarification processes in biopharmaceutical manufacturing through quality by design: Strategies, implications, and future prospects

Biotechnology Progress, EarlyView.
Abstract Biopharmaceutical manufacturing processes in which the product of interest is extracellularly expressed typically employ a clarification step following cell culture or fermentation. During clarification, crude cell culture fluid or fermentation broth is processed to remove insoluble solids, cells, debris, and other particulates, with the ...
Kyeong‐won Yeop, Hyun‐ju Nam, Chang‐jae Shim, So‐mi Yang, Hyo‐won Kim, Cheon Ik Park, Subhasis Banerjee, Yanglin Mok   +7 more
wiley   +1 more source

Scalable production and biophysical characterization of an enzyme cocktail derived from human red blood cells

Biotechnology Progress, EarlyView.
Abstract Red blood cells (RBCs) play a critical role in oxygen and carbon dioxide transport, which is facilitated by RBC‐encapsulated hemoglobin (Hb) and carbonic anhydrase (CA). In addition, RBCs are constantly exposed to oxidative stress due to the intracellular reactive oxygen species (ROS) generated during Hb auto‐oxidation.
Mohd Asim Khan, Griffin J. Beyer, Naomi Goosby, Lilly Ortiz, Andre F. Palmer   +4 more
wiley   +1 more source

The Applications of Fluorescent Antibody Techniques in Bacteriology and Virology

, 1963
A. E. Wilkinson
openalex   +2 more sources

An outbreak of aseptic meningitis associated with Coxsackie B5 and A9 viruses in Northern Japan, 1961. Virological and serological studies [PDF]

, 1964
Yorio Hinuma, Yoshimichi Murai, Minoru Fukuda, Yoshio Numazaki, Nakao Ishida, Tooru Nakao   +5 more
openalex   +1 more source

Scale‐up of a monoclonal antibody CHO fed‐batch production in stirred tank bioreactors: Effect of hydrodynamic conditions and feeding regimen

Biotechnology Progress, EarlyView.
Abstract Key hydrodynamic‐related parameters such as volumetric power input (P/V), impeller configuration, aeration strategy, and maximum gas sparge rate, as well as an appropriate feeding strategy, must be carefully selected to improve production yields in bioreactor.
Lucas Lemire, Sebastian‐Juan Reyes, Yves Durocher, Robert Voyer, Olivier Henry, Phuong Lan Pham   +5 more
wiley   +1 more source

Formalinized red cells in diagnostic virology. [PDF]

, 1966
David W. A. Beno, Earl A. Edwards
openalex   +2 more sources

Selected Papers On Virology [PDF]

, 1964
Herbert C. Barnett
openalex   +1 more source

Functional CRISPR‐Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity

Biotechnology Progress, EarlyView.
Abstract Directional cell migration plays a central role in a wide range of physiological and pathological conditions, such as embryonic development or tumor metastasis. Steps involved in cell migration include cell polarization, formation of membrane protrusions at the cell front side and adhesion disassembly at the rear side, and a general ...
Antonio Mazzei, Sebastian Martewicz, Ramin Amiri, Meihua Cui, Nicola Elvassore, Camilla Luni   +5 more
wiley   +1 more source

Automation of an integrated micro‐scale platform for monoclonal antibody process development by incorporation of a depth filter mimic

Biotechnology Progress, EarlyView.
Integrating non‐chromatographic operations, such as low pH viral inactivation and a depth filtration mimic, into an automated micro‐scale platform enhances productivity while reducing resource and time requirements. By facilitating rapid, data‐rich experimentation, the platform offers a powerful and efficient tool for assessing and optimizing ...
Paras Sharma, Petra Sebastian, Lars Robbel, Michael Schmitt, Daniel G. Bracewell   +4 more
wiley   +1 more source

APPLICATIONS OF IMMUNOFLUORESCENCE IN PUBLIC HEALTH VIROLOGY [PDF]

, 1964
Morris Schaeffer, Ernest V. Orsi, Daniel Widelock   +2 more
openalex   +1 more source