Results 151 to 160 of about 462,924 (342)

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

TimeFlow 2: An Unsupervised Cell Lineage Detection Method for Flow Cytometry Data

Cytometry Part A, EarlyView.
TimeFlow 2 is a new method for cell lineage inference in flow cytometry data. It constructs cell state paths along pseudotime and aggregates them into biologically informative groups. It allows tracking of cytometry markers within each automatically inferred lineage.
Margarita Liarou, Thomas Matthes, Stéphane Marchand‐Maillet   +2 more
wiley   +1 more source

Virologic Response Using Directly Observed Therapy in Adolescents With HIV: An Adherence Tool

, 2008
Julia Purdy, Alexandra F. Freeman, Staci Martin, Celia Ryder, Deborah K. Elliott-DeSorbo, Steven L. Zeichner, Rohan Hazra   +6 more
openalex   +1 more source

Is Virology Dead?

mBio, 2014
Daniel DiMaio
doaj   +1 more source

Plasma Lopinavir Concentrations Predict Virological Failure in a Cohort of South African Children Initiating a Protease-Inhibitor-Based Regimen

, 2013
Retsilisitsoe R. Moholisa, Michael Schomaker, Louise Kuhn, Sandra Meredith, Lubbe Wiesner, Ashraf Coovadia, Renate Strehlau, Leigh Martens, Elaine J. Abrams, Gary Maartens, Helen McIlleron   +10 more
openalex   +1 more source

Clinical and virologic effects of four neuraminidase inhibitors in influenza A virus-infected children (aged 4–12 years): an open-label, randomized study in Japan [PDF]

, 2017
Nobuo Hirotsu, Yutaka Saisho, Takahiro Hasegawa, Takao Shishido   +3 more
openalex   +1 more source

Evaluation of the dynamic pattern of viral evolution in patients with virological breakthrough during treatment with nucleoside/nucleotide analogs by ultra-deep pyrosequencing

, 2015
Shao‐Long Chen, Jing Wu, Erli Gu, Yaojie Shen, Feifei Wang, Wenhong Zhang   +5 more
openalex   +2 more sources

Early matrine intervention of gut microbiota for type 2 diabetes prevention

iMetaOmics, EarlyView.
How matrine influences gut microbiota imbalance to prevent the progression of diabetes remains unclear. We conduct experiments using mice to simulate the stages of diabetes development and matrine intervention. Combined with amplicon sequencing, we find that the gut microbiota of diabetic mice continuously changes with the progression of the disease ...
Zhexue Sun, Hujie Lyu, Hailang Xu, Xianjin Qin, Wei Li   +4 more
wiley   +1 more source

The kidney in hantavirus infection—epidemiology, virology, pathophysiology, clinical presentation, diagnosis and management [PDF]

, 2022
Felix C. Koehler, Veronica Di Cristanziano, Martin R. Späth, Karla Johanna Ruth Hoyer-Allo, Manuel Wanken, Roman‐Ulrich Müller, Volker Burst   +6 more
openalex   +1 more source

Metagenomic mining reveals novel Cas12 subtypes and their evolutionary diversification

iMetaOmics, EarlyView.
We identified 4112 Cas12 Proteins and 6 new Cas12 subtypes, revealed their significant diversity in N‐terminal regions, repeat sequences, and sequences motifs. We developed an AI‐driven algorithm, Cas12fam, which allows precise annotation of 18 distinct domains in Cas12 proteins.
Meixia Yu, Zilong Zhao, Peiyang Li, Yunpeng Teng, Feng Xu, Zhimeng Li, Zhijia Yang, Hainan Zhao, Huanbin Zhou, Lanqin Xia, Jinsheng Lai, Beibei Xin   +11 more
wiley   +1 more source