Results 51 to 60 of about 520,593 (330)

Retroviral Antisense Transcripts and Genes: 33 Years after First Predicted, a Silent Retroviral Revolution?

Viruses, 2021
Paradigm shifts throughout the history of microbiology have typically been ignored, or met with skepticism and resistance, by the scientific community.
Roger H. Miller, Alexis Zimmer, Gilles Moutot, Jean-Michel Mesnard, Nathalie Chazal   +4 more
doaj   +1 more source

Microfluidics in Single-Cell Virology: Technologies and Applications.

Trends in Biotechnology, 2020
Microfluidics has proven to be a powerful tool for probing biology at the single-cell level. However, it is only in the past 5 years that single-cell microfluidics has been used in the field of virology.
Wu Liu, Hongzhang He, Si-Yang Zheng
semanticscholar   +1 more source

Genetic diversity of Brazilian isolates of feline immunodeficiency virus [PDF]

, 2010
We isolated Feline immunodeficiency virus (FIV) from three adult domestic cats, originating from two open shelters in Brazil. Viruses were isolated from PBMC following co-cultivation with the feline T-lymphoblastoid cell line MYA-1.
A Duarte, A Reche Jr, AN Martins, B. J. Willett, BJ Willett, BJ Willett, BM Teixeira, Bruno Marques Teixeira, C Palmer, DL Lerner, DL Sodora, EA Weaver, EJ Verschoor, F Reggeti, FA Caxito, G Pancino, G Ryan, GA Dean, J. C. M. Cruz, J. K. P. Reis, JH Elder, JJ Hayward, JK Yamamoto, KH Siebelink, L. J. Richtzenhain, M Goodenow, M Torten, M. J. Hosie, M. K. Hagiwara, MA Rigby, MJ Hosie, MJ Hosie, MJ Hosie, MR Pecoraro, MT Kyaw-Tanner, MW Cho, N. Logan, NC Pedersen, P. E. Brandão, R Kann, RA Olmsted, RL Talbott, RV English, S Kakinuma, S Lombardi, T Hohdatsu, T Hohdatsu, T Miyazawa, TA Hall, W Huisman, WK Greene   +50 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Modelling and in vitro testing of the HIV-1 Nef fitness landscape. [PDF]

, 2019
An effective vaccine is urgently required to curb the HIV-1 epidemic. We have previously described an approach to model the fitness landscape of several HIV-1 proteins, and have validated the results against experimental and clinical data.
Barton, John P, Chakraborty, Arup K, Mahiti, Macdonald, Mann, Jaclyn K, Murakowski, Dariusz K, Mwimanzi, Phillip, Ndung'u, Thumbi, Rajkoomar, Erasha, Toyoda, Mako, Ueno, Takamasa   +9 more
core   +2 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Changes on the viral capsid surface during the evolution of porcine circovirus type 2 (PCV2) from 2009 till 2018 may lead to a better receptor binding [PDF]

, 2019
Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated diseases (PCVAD). Three major PCV2 genotypes (PCV2a, PCV2b, and PCV2d) have been identified globally.
Nauwynck, Hans, Theuns, Sebastiaan, Wei, Ruifang, Xie, Jiexiong   +3 more
core   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Virus goes viral: an educational kit for virology classes

Virology Journal, 2020
Viruses are the most numerous entities on Earth and have also been central to many episodes in the history of humankind. As the study of viruses progresses further and further, there are several limitations in transferring this knowledge to undergraduate
Gabriel Augusto Pires de Souza, V. Queiroz, M. Lima, Erik Vinicius de Sousa Reis, L. Coelho, J. Abrahão   +5 more
semanticscholar   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source