Results 51 to 60 of about 332,784 (298)
Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity
Advanced Science, EarlyView.Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao +14 morewiley +1 more sourceRecommendations for the introduction of metagenomic high-throughput sequencing in clinical virology, part I: Wet lab procedure [PDF]
, 2020 Metagenomic high-throughput sequencing (mHTS) is a hypothesis-free, universal pathogen detection technique for determination of the DNA/RNA sequences in a variety of sample types and infectious syndromes.Claas, E.C.J., Cinek, O., Feltkamp, Mariet C.W., Nielsen, XC, Jonges, M., Claas, Eric C J, Jonges, M, Leuzinger, K, Klapper, Paul E., Buesa, J, Kamminga, S., van der Hoek, L, Fischer, Nicole, Xavier Lopez-Labrador, F., Simmonds, P, Klapper, P.E., Brown, JR, Hoper, D., Hoeper, D, Kufner, V, Auvinen, Eeva, Van Boheemen, S, Sousa, Hugo, Rodriguez-Diaz, Jesus, Schuurman, R., Höper, D, ESCV Network Next-Generation Seque, Kamminga, S, Keyaerts, E, Puchhammer-Stockl, E, Hönemann, Mario, Huber, Michael, Schuurman, R, Brown, Julianne R., Feltkamp, Mariet C. W., de Vries, Jutte J C, Sayiner, A, Breuer, J, de Vries, J, Kroes, Aloys C. M., Keyaerts, E., Klapper, PE, Perez-Cataluna, Alba, Hoeper, Dirk, Pérez-Catalu?a, A, van der Hoek, Lia, Madsen, T.V., Hernandez, Marta, Kroes, Aloys C.M., Hoek, L. van der, Huber, M, Van Boheemen, Sander, Nielsen, Xiaohui Chen, Couto, N., Feltkamp, M.C.W., Fischer, N., Sayiner, Arzu, SAYINER, AYÇA ARZU, Buesa, Javier, Vries, J.J.C. de, Harvala, H., Nielsen, X.C., Molenkamp, Richard; id_orcid, Beer, M, Cinek, Ondrej, Lopez-Labrador, F.X., Molenkamp, R., Schuurman, R (Rob), Rodriguez-Diaz, J, Rodriguez-Diaz, J., de Vries, Jutte J.C., Claas, Eric C.J., Sousa, H, Sayiner, A., Rodriguez, C., Brown, Julianne R, Harvala, Heli, de Vries, JJC, Molenkamp, R, Cinek, O, Brown, J.R., Leuzinger, K., Perez-Cataluna, A, Jonges, Marcel, Hoenemann, Mario, Höper, Dirk, López-Labrador, FX, Molenkamp, Richard, Puchhammer-Stockl, Elisabeth, Kroes, Aloys C M, de Vries, Jutte J. C., Couto, Natacha, Kufner, V., Kufner, Verena, Buesa, J., Hoenemann, M, Puchhammer-Stockl, E., Beer, Martin, Boheemen, S. van, Auvinen, E, Susi, Petri, Kamminga, Sergio, Xavier Lopez-Labrador, F, Madsen, TV, Rodriguez, Christophe, Harvala, H, Honemann, M., Huber, M., Couto, N, Breuer, J., Fischer, N, Rodriguez, C, der Hoek, Lia van, Claas, ECJ, Claas, Eric C. J., Hernandez, M., Beer, M., Simmonds, Peter, Susi, P, Sousa, H., Feltkamp, MCW, Keyaerts, Els, Hernandez, M, Leuzinger, Karoline, Auvinen, E., der Hoek, LV, Kroes, AC, Madsen, Tina Vasehus, Klapper, Paul E, Perez-Cataluna, A., Schuurman, Rob, Kroes, A.C.M., Kroes, ACM, Hönemann, M, Feltkamp, Mariet C W, López-Labrador, F Xavier, et al, Breuer, Judy, Simmonds, P., Susi, P. +139 morecore +3 more sourcesEndowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli
Advanced Science, EarlyView.Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu +18 morewiley +1 more sourceSarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation
Advanced Science, EarlyView.Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma +24 morewiley +1 more sourceThe birth of virology
Antonie van Leeuwenhoek, 1997 This quote is from Cicero’s ‘De Amicitia’ (23, 87) — I happen to remember it from my days at school, and it comes in conveniently to start a talk on the birth of virology, my occupation since three decades. In Cicero’s quote it is said of an intransigent person that she ‘...still cannot be without somebody where to spit out the venom of one’s own ...openaire +3 more sourcesAn Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir
Advanced Science, EarlyView.FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi +13 morewiley +1 more sourceGapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir
Advanced Science, EarlyView.We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang +15 morewiley +1 more sourceCerebrospinal Fluid Cytokine Expression and Relationships With Neurological Measures in Virologically Controlled People With HIV
Annals of Neurology, EarlyView.Objective
Quantify cytokines in cerebrospinal fluid (CSF) of virologically suppressed people with HIV (PWH) and people without HIV (PWoH) and correlate these with neuroimaging, neuropsychometric (NP), and neurodegenerative measurements. Methods
CSF samples were collected from virologically suppressed PWH and demographically matched PWoH under a natural Jack Peterson, Clarissa Xia, Govind Nair, Joseph Snow, Julia Stone, Gina Norato, Brandon Do, Samuel Darko, Kory Johnson, Swati Shah, Amanda Wiebold, Melina Jones, Avindra Nath, Darshan Pandya +13 morewiley +1 more source
