Results 61 to 70 of about 325,358 (303)

Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2

iScience, 2021
Summary: Global deployment of an effective and safe vaccine is necessary to curtail the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Jun-Gyu Park, Fatai S. Oladunni, Mohammed A. Rohaim, Jayde Whittingham-Dowd, James Tollitt, Matthew D.J. Hodges, Nadin Fathallah, Muhsref Bakri Assas, Wafaa Alhazmi, Abdullah Almilaibary, Munir Iqbal, Pengxiang Chang, Renee Escalona, Vinay Shivanna, Jordi B. Torrelles, John J. Worthington, Lucy H. Jackson-Jones, Luis Martinez-Sobrido, Muhammad Munir   +18 more
doaj   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

The Present and Future of Virology in the Czech Republic—A New Phoenix Made of Ashes?

, 2022
The Czech Republic, a part of the former Czechoslovakia, has been at the forefront of several research directions in virology, genetics and physiology [...
Tomas Ruml, Ruml Tomas, Ruml, Tomas
core   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Clinical, Virological, and Immunological Findings in Patients with Toscana Neuroinvasive Disease in Croatia: Report of Three Cases

Tropical Medicine and Infectious Disease, 2020
Toscana virus (TOSV) is an arthropod-borne virus, transmitted to humans by phlebotomine sandflies. Although the majority of infections are asymptomatic, neuroinvasive disease may occur.
Tatjana Vilibic-Cavlek, Snjezana Zidovec-Lepej, Dragan Ledina, Samira Knezevic, Vladimir Savic, Irena Tabain, Ivo Ivic, Irena Slavuljica, Maja Bogdanic, Ivana Grgic, Lana Gorenec, Vladimir Stevanovic, Ljubo Barbic   +12 more
doaj   +1 more source

WSV2023 - The second meeting of the world society for virology: One health - One world - One virology [PDF]

6 Pág.The Second International Conference of the World Society for Virology (WSV), hosted by Riga Stradiņš University, was held in Riga, Latvia, on June 15-17th, 2023.
Kuhn, Richard J., Vakharia, V.N., Saxena, Shailendra K., Söderlund-Venermo, Maria, Varma, Anupam, Murovska, Modra, Saxena, Shailendra, Alonso, Covadonga, Vakharia, Vikram N., Kuhn, Richard, Alonso Martí, Covadonga, Gladue, Douglas P., Zhengli, Shi, Moore, Matthew D., Abdelwahab, Sayed, Gladue, D. P., Moore, Matthew, Wilson, William C., Venter, Marietjie, Malik, Yashpal, Abdelwahab, Sayed F., Abdel-Moneim, Ahmed S., Malik, Yashpal S.   +22 more
core   +1 more source

Development survey of neurovirology

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
As a new subdiscipline, neurovirology derives from medical virology and neurology. Its research field includes both clinical practice of viral infectious diseases of the nervous system and fundamental research of medical virology.
De-xin WANG
doaj  

Multicenter Italian Study on “In Vitro Activities” of Isavuconazole, Voriconazole, Amphotericin B, and Caspofungin for Aspergillus Species: Comparison between SensititreTM YeastOneTM and MIC Test Strip

Infection and Drug Resistance, 2022
Giuliana Lo Cascio,1– 3 Alda Bazaj,1 Laura Trovato,2,4 Silvana Sanna,2,5 Stefano Andreoni,2,6 Elisabetta Blasi,2,7 Marco Conte,2,8 Paolo Fazii,2,9 Ester Oliva,10 Valentina Lepera,11 Gianluigi Lombardi,2,11 Claudio Farina2,10 1Clinical Microbiology and ...
Lo Cascio G, Bazaj A, Trovato L, Sanna S, Andreoni S, Blasi E, Conte M, Fazii P, Oliva E, Lepera V, Lombardi G, Farina C   +11 more
doaj  

Differential In Vitro Infection of Neural Cells by Astroviruses

mBio, 2019
Recent advances in unbiased pathogen discovery have implicated astroviruses as pathogens of the central nervous system (CNS) of mammals, including humans.
Andrew B. Janowski, Robyn S. Klein, David Wang   +2 more
doaj   +1 more source