Results 71 to 80 of about 520,593 (330)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

50 years of the International Committee on Taxonomy of Viruses: progress and prospects [PDF]

, 2017
We mark the 50th anniversary of the International Committee on Taxonomy of Viruses (ICTV) by presenting a brief history of the organization since its foundation, showing how it has adapted to advancements in our knowledge of virus diversity and the ...
Adams, Michael J., Davison, Andrew J., Gorbalenya, Alexander E., Harrach, Balázs, Harrison, Robert L., King, Andrew M.Q., Knowles, Nick J., Kropinski, Andrew M., Krupovic, Mart, Kuhn, Jens H., Lefkowitz, Elliot J., Mushegian, Arcady R., Nibert, Max L., Orton, Richard J., Sabanadzovic, Sead, Sanfaçon, Hélène, Siddell, Stuart G., Simmonds, Peter, Smith, Donald B., Varsani, Arvind, Zerbini, Francisco Murilo   +20 more
core   +5 more sources

Establishment of a brain cell line (FuB-1) from mummichog (Fundulus heteroclitus) and its application to fish virology, immunity and nanoplastics toxicology.

Science of the Total Environment, 2019
The marine fish mummichog (Fundulus heteroclitus), extensively used as research model, including in ecotoxicology, for over a century has been surpassed by other fish species.
M. Ruíz-Palacios, Mónica Almeida, M. Martins, Miguel Oliveira, M. Esteban, A. Cuesta   +5 more
semanticscholar   +1 more source

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses

eLife, 2018
Type I interferon (IFN-I) responses are critical for the control of RNA virus infections, however, many viruses, including Dengue (DENV) and Chikungunya (CHIKV) virus, do not directly activate plasmacytoid dendritic cells (pDCs), robust IFN-I producing ...
Brian Webster, Scott W Werneke, Biljana Zafirova, Sébastien This, Séverin Coléon, Elodie Décembre, Helena Paidassi, Isabelle Bouvier, Pierre-Emmanuel Joubert, Darragh Duffy, Thierry Walzer, Matthew L Albert, Marlène Dreux   +12 more
doaj   +1 more source

virology

, 2022
doc
openaire   +1 more source

Serum Bile Acids Are Useful Indicators of Intrahepatic Recurrence After Initial Curative Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Bile acids accumulation in hepatocytes causes liver damage and contributes to the development of hepatocellular carcinoma. However, the association between serum bile acid levels and postoperative intrahepatic recurrence in hepatocellular carcinoma remains unclear.
Tomoaki Bekki, Masahiro Ohira, Yuki Imaoka, Seiichi Simizu, Tomoyuki Abe, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Hideki Ohdan   +9 more
wiley   +1 more source

Multicenter Italian Study on “In Vitro Activities” of Isavuconazole, Voriconazole, Amphotericin B, and Caspofungin for Aspergillus Species: Comparison between SensititreTM YeastOneTM and MIC Test Strip

Infection and Drug Resistance, 2022
Giuliana Lo Cascio,1– 3 Alda Bazaj,1 Laura Trovato,2,4 Silvana Sanna,2,5 Stefano Andreoni,2,6 Elisabetta Blasi,2,7 Marco Conte,2,8 Paolo Fazii,2,9 Ester Oliva,10 Valentina Lepera,11 Gianluigi Lombardi,2,11 Claudio Farina2,10 1Clinical Microbiology and ...
Lo Cascio G, Bazaj A, Trovato L, Sanna S, Andreoni S, Blasi E, Conte M, Fazii P, Oliva E, Lepera V, Lombardi G, Farina C   +11 more
doaj  

Viral Evasion of the Complement System and Its Importance for Vaccines and Therapeutics

Frontiers in Immunology, 2020
The complement system is a key component of innate immunity which readily responds to invading microorganisms. Activation of the complement system typically occurs via three main pathways and can induce various antimicrobial effects, including ...
Jack Mellors, Jack Mellors, Tom Tipton, Stephanie Longet, Miles Carroll   +4 more
doaj   +1 more source

Islands of linkage in an ocean of pervasive recombination reveals two-speed evolution of human cytomegalovirus genomes [PDF]

, 2016
Human cytomegalovirus (HCMV) infects most of the population worldwide, persisting throughout the host's life in a latent state with periodic episodes of reactivation.
Atkinson, Claire, Balloux, Francois, Breuer, Judith, Brown, Amanda C., Brown, Julianne R., Christiansen, Mette T., Clark, Duncan A., Depledge, Daniel P., Einer-Jensen, Katja, Griffiths, Paul D., Holdstock, Jolyon, Lassalle, Florent, Milne, Richard S.B., Reeves, Matthew B., Schutten, Martin, Tutill, Helena J., van Loenen, Freek B., Verjans, Georges M.G.M., Williams, Rachel J.   +18 more
core   +1 more source