Commensal Viruses Promote Intestinal Stem Cell Regeneration Following Radiation Damage by Inhibiting Hyperactivation of RIG‐I and Notch Signals [PDF]
Advanced ScienceRadiation‐induced intestinal injury is a common complication of abdominopelvic cancer radiotherapy, often associated with gut bacteriome dysbiosis. However, the involvement of gut virome in this process remains largely underexplored.
Xiaotong Zhao +17 more
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Viruses, 2023 Virome research is a rapidly growing area in the microbiome field that is increasingly associated with human diseases, such as inflammatory bowel disease (IBD).
Daan Jansen, Jelle Matthijnssens
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Longitudinal cervicovaginal bacteriome and virome alterations associate with discordant shedding and ART duration in women living with HIV in Peru [PDF]
Nature CommunicationsDespite successful suppression of plasma HIV replication by antiretroviral therapy (ART), some women living with HIV (WLHIV) can still experience genital HIV shedding (discordant shedding).
Emily A. Kaelin +8 more
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The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features [PDF]
Gut MicrobesThe mucosal virome is increasingly recognized for its potential role in shaping intestinal health and disease. Building on previous findings, we analyzed the mucosal virome from 51 individuals, including newly diagnosed treatment naïve participants with ...
Austin Yan +3 more
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Metagenomic next-generation sequencing-based characterization of the viral spectrum in clinical pulmonary and peripheral blood samples of patients [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundMetagenomic next-generation sequencing (mNGS) enables comprehensive profiling of viral communities in clinical samples. However, comparative analyses of the virome across anatomical compartments and disease states remain limited.
Ning Zheng +10 more
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Virome drift in ulcerative colitis patients: faecal microbiota transplantation results in minimal phage engraftment dominated by microviruses [PDF]
Gut MicrobesUlcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent colonic inflammation. Standard treatments focus on controlling inflammation but remain ineffective for one-third of patients.
Daan Jansen +10 more
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Virome genomics: a tool for defining the human virome
Current Opinion in Microbiology, 2013 High throughput, deep sequencing assays are powerful tools for gaining insights into virus-host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be characterized, describe important genes in the host that control infections, and ...
Kristine M. Wylie +2 more
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Gut virome alterations in patients with chronic obstructive pulmonary disease
Microbiology SpectrumChronic obstructive pulmonary disease (COPD) is one of the primary causes of mortality and morbidity worldwide. The gut microbiome, particularly the bacteriome, has been demonstrated to contribute to the progression of COPD. However, the influence of gut
Yue Liu +14 more
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Human virome: Implications in cancer
Heliyon, 2023 In recent years, the human virome has gained importance, especially after the SARS-CoV-2 pandemic, due to its possible involvement in autoimmune, inflammatory diseases, and cancer.
Rafael Tamayo-Trujillo +5 more
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Comparative metagenomic analysis using VIROME v1 [PDF]
, 2015 This tutorial explainshow to download entire libraries of data from the VIROME web application. Wommack, K. E., J. Bhavsar, S. W. Polson, J. Chen, M. Dumas, S. Srinivasiah, M. Furman, S. Jamindar, and D. J. Nasko. 2012. VIROME: a standard operating procedure for analysis of viral metagenome sequences.
Jaysheel Bhavsar +2 more
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