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[The antiviral targeting potential of viroporins].
Ugeskrift for laeger, 2022Viroporins are ion channels found in many viruses, where they contribute to virus life cycle and thereby pathogenesis. Viroporin targeting is a known, yet largely unexplored, therapeutic strategy so far only used in Influenza A with the drugs amantadine and rimantadine.
John D, Sund +9 more
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Lipid composition modulates interactions of p7 viroporin during membrane insertion
Journal of Structural Biology, 2023Viral proteins interact with lipid membranes during various stages in the viral life cycle to propagate infection. p7 is an ion channel forming protein of Hepatitis C virus (HCV) that participates in viral assembly. Studies show that it has close ties to lipid metabolism in the cell and anionic phosphatidylserine (PS) lipids are suggested to be key for
Oluwatoyin Campbell +1 more
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Functional and Structural Characterization of 2B Viroporin Membranolytic Domains
Biochemistry, 2008Nonstructural 2B viroporin is an intracellularly produced pore-forming protein required for effective enteroviral and rhinoviral replication. The sequence of 2B displays two putative interconnected transmembrane domains, which are predicted to insert into the negatively charged membranes of target organelles forming an integral hairpin.
Silvia, Sánchez-Martínez +5 more
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Oligomeric states of an Influenza-encoded PB1-F2 viroporin
2023ABSTRACTInfluenza Viruses have always been a major health concern due to their highly contagious nature. The PB1-F2 viroporin encoded by the influenza A virus is known to be a pro-apoptotic protein involved in cell death induction of the host immune cells.
Sehrish Jamal +2 more
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Membrane Proteome: A Funnel-like Viroporin
PSI Structural Genomics KnowledgeBase, 2013openaire +1 more source