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An oncolytic herpesvirus expressing a CXCR4 antagonist interferes with glioblastoma cells' stemness features and migration. [PDF]
Mol Ther OncolD'arrigo P +10 more
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Personalizing Oncolytic Virotherapy
Human Gene Therapy, 2023 The use of oncolytic viruses has become an attractive tool in the clinics for the treatment of various tumor types. Such viruses are genetically modified to conditionally replicate in malignant cells while unharming healthy cells.
Firas Hamdan, M. Fusciello, V. Cerullo
semanticscholar +5 more sources
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2023
Oncolytic virotherapy opens up avenues for cancer treatment by selectively targeting the cancer cells and destructs them either through direct lysis or by inducing an immune response in the tumor microenvironment. This platform technology utilizes a diverse range naturally existing or genetically modified oncolytic viruses for their immunotherapeutic ...
Munazza, Fatima +2 more
openaire +3 more sources
Oncolytic virotherapy opens up avenues for cancer treatment by selectively targeting the cancer cells and destructs them either through direct lysis or by inducing an immune response in the tumor microenvironment. This platform technology utilizes a diverse range naturally existing or genetically modified oncolytic viruses for their immunotherapeutic ...
Munazza, Fatima +2 more
openaire +3 more sources
Journal of Vascular and Interventional Radiology, 2013
Oncolytic virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral ...
Daniel Y, Sze +2 more
openaire +2 more sources
Oncolytic virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral ...
Daniel Y, Sze +2 more
openaire +2 more sources
Poxvirus oncolytic virotherapy
Expert Opinion on Biological Therapy, 2019Over the last decade, advances in biological therapies have resulted in remarkable clinical responses for the treatment of some previously incurable cancers. Oncolytic virotherapy is one of these promising novel strategies for cancer therapy. A successful oncolytic virus promotes tumor cell oncolysis and elicits a robust long-term anti-tumor immunity ...
Lino E, Torres-Domínguez +1 more
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Oncolytic virotherapies for pediatric tumors
Expert Opinion on Biological Therapy, 2023Many pediatric patients with malignant tumors continue to suffer poor outcomes. The current standard of care includes maximum safe surgical resection followed by chemotherapy and radiation which may be associated with considerable long-term morbidity.
Evan G Gross +6 more
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Oncolytic virotherapy: Challenges and solutions
Current Problems in Cancer, 2021Viruses as cancer therapies have attracted attention since the 19th century. Scientists observation that viruses can preferentially lyse cancer cells rather than healthy cells, created the field of oncolytic virology. Like other therapeutic strategies, oncolytic virotherapy has challenges, such as penetration into tumor bulk, anti-viral immune ...
Nasser Hashemi Goradel +5 more
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Oncolytic virotherapy reaches adolescence
Pediatric Blood & Cancer, 2010AbstractLytic viruses kill cells as a consequence of their normal replication life cycle. The idea of harnessing viruses to kill cancer cells arose over a century ago, before viruses were even discovered, from medical case reports of infections associated with cancer remissions.
Adrienne M, Hammill +2 more
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2018
Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type and non-engineered in vitro-passaged virus strains and vaccine strains (first generation oncolytic viruses ...
Daisuke, Watanabe, Fumi, Goshima
openaire +2 more sources
Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type and non-engineered in vitro-passaged virus strains and vaccine strains (first generation oncolytic viruses ...
Daisuke, Watanabe, Fumi, Goshima
openaire +2 more sources
Optimization of Virotherapy for Cancer
Bulletin of Mathematical Biology, 2009Several viruses preferentially infect and replicate in cancer cells by usurping pathways that are defective in the tumor cell population. Such viruses have a potential as oncolytic agents. The aim of tumor virotherapy is that after injection of the replicating virus, it propagates in the tumor cell population with amplification.
Biesecker, Matt +4 more
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