Results 271 to 280 of about 18,764 (290)
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International Journal of Molecular Sciences
Head and neck cancer (HNC) represents a challenging oncological entity with significant morbidity and mortality rates. Despite advances in conventional therapies, including surgery, chemotherapy, and radiation therapy, the overall survival rates for ...
F. Spirito +10 more
semanticscholar +1 more source
Head and neck cancer (HNC) represents a challenging oncological entity with significant morbidity and mortality rates. Despite advances in conventional therapies, including surgery, chemotherapy, and radiation therapy, the overall survival rates for ...
F. Spirito +10 more
semanticscholar +1 more source
Virotherapy of Neuroendocrine Tumors
Neuroendocrinology, 2012Most patients with small intestinal neuroendocrine tumors (SI-NETs), also referred to as midgut carcinoids, present with systemic disease at the time of diagnosis with metastases primarily found in regional lymph nodes and the liver. Curative treatment is not available for these patients and there is a need for novel and specific therapies.
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Introduction to Oncolytic Virotherapy
2019Oncolytic viruses exploit key hallmarks of cancer for replication in malignant cells, leading to tumor cell lysis, modulation of the tumor microenvironment and in situ vaccination effects. Diverse virus platforms have been developed as oncolytic vectors and designed for improved tumor specificity, intratumoral spread, therapeutic gene delivery and ...
Christine E, Engeland, John C, Bell
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Oncolytic virotherapy in lung cancer
2023Lung tumors are one of the most aggressive threats affecting humans. Current therapeutic approaches have improved patients' survival; however, further efforts are required to increase effectiveness and protection against tumor relapse and metastasis. Immunotherapy presents an alternative to previous treatments that focuses on stimulating of the patient'
Estanislao, Nistal-Villan +2 more
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Oncolytic virotherapy of gynecologic malignancies
Gynecologic Oncology, 2011Gynecologic cancer is still the third leading cause of cancer death among women in the US. Therapeutics employing novel mechanisms of action are therefore urgently needed. Oncolytic viruses (OVs) selectively infecting and replicating in cancer cells have recently attracted considerable interest as promising anti-cancer agents.
Andreas D, Hartkopf +3 more
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Oncolytic virotherapy for multiple myeloma
Expert Opinion on Biological Therapy, 2008Current therapies for multiple myeloma (MM) are not curative, thus novel targeted therapeutics are being developed. One such targeted therapy is oncolytic virotherapy, wherein viruses specifically infect and kill the malignant plasma cells, leaving normal cells intact.This review provides an overview of the mechanisms and results of the oncolytic ...
Amaalia E, Stief, J Andrea, McCart
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Mathematical Modeling of Oncolytic Virotherapy
2019Mathematical modeling in biology has a long history as it allows the analysis and simulation of complex dynamic biological systems at little cost. A mathematical model trained on experimental or clinical data can be used to generate and evaluate hypotheses, to ask "what if" questions, and to perform in silico experiments to guide future experimentation
Johannes P W, Heidbuechel +3 more
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Immunomodulation in Oncolytic Measles Virotherapy
2019With the recognition of oncolytic virotherapy as an immunotherapy, the distinct interactions between oncolytic agents and the immune system have come into focus. The role of the immune system in oncolytic virotherapy is somewhat ambiguous: While preexisting or arising immunity directed against viral antigens may preclude efficient viral replication and
Laura, Dietz, Christine E, Engeland
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Potential targeting of the tumor microenvironment to improve cancer virotherapy.
Pharmacology and Therapeutics, 2023Z. Liao +5 more
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