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What is oncolytic virotherapy? [PDF]
Archives of disease in childhood - Education & practice edition, 2017 It has long been hypothesised that viruses may have a role in treating cancer. From the mid-1800s, there has been documentation of patients undergoing spontaneous cancer remission following severe infection, and by the start of the 20th century, a temporary complete remission of acute leukaemia was observed in a patient suffering from influenza.1 Over ...
Julia V. Cockle, Karen Scott
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Journal of Vascular and Interventional Radiology, 2013
Oncolytic virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral ...
Steven C. Rose +2 more
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Oncolytic virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral ...
Steven C. Rose +2 more
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Optimization of Virotherapy for Cancer
Bulletin of Mathematical Biology, 2009Several viruses preferentially infect and replicate in cancer cells by usurping pathways that are defective in the tumor cell population. Such viruses have a potential as oncolytic agents. The aim of tumor virotherapy is that after injection of the replicating virus, it propagates in the tumor cell population with amplification.
Huitian Lu +4 more
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Poxvirus oncolytic virotherapy
Expert Opinion on Biological Therapy, 2019Over the last decade, advances in biological therapies have resulted in remarkable clinical responses for the treatment of some previously incurable cancers. Oncolytic virotherapy is one of these promising novel strategies for cancer therapy. A successful oncolytic virus promotes tumor cell oncolysis and elicits a robust long-term anti-tumor immunity ...
Lino E. Torres-Dominguez, Grant McFadden
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2018
Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type and non-engineered in vitro-passaged virus strains and vaccine strains (first generation oncolytic viruses ...
Fumi Goshima, Daisuke Watanabe
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Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type and non-engineered in vitro-passaged virus strains and vaccine strains (first generation oncolytic viruses ...
Fumi Goshima, Daisuke Watanabe
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Virotherapy of Neuroendocrine Tumors
Neuroendocrinology, 2012Most patients with small intestinal neuroendocrine tumors (SI-NETs), also referred to as midgut carcinoids, present with systemic disease at the time of diagnosis with metastases primarily found in regional lymph nodes and the liver. Curative treatment is not available for these patients and there is a need for novel and specific therapies.
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Introduction to Oncolytic Virotherapy
2019Oncolytic viruses exploit key hallmarks of cancer for replication in malignant cells, leading to tumor cell lysis, modulation of the tumor microenvironment and in situ vaccination effects. Diverse virus platforms have been developed as oncolytic vectors and designed for improved tumor specificity, intratumoral spread, therapeutic gene delivery and ...
John C. Bell +2 more
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Systemic virotherapy for multiple myeloma
Expert Opinion on Biological Therapy, 2017The multiple myeloma (MM) treatment scenario has changed considerably over the past few years. Several novel targeted therapies are currently under consideration including oncolytic virotherapy. Areas covered: This review provides an analysis of the mechanisms of action of virotherapy, and summarizes the preclinical and clinical studies of systemic ...
Oliva S +3 more
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Oncolytic virotherapy of gynecologic malignancies
Gynecologic Oncology, 2011Gynecologic cancer is still the third leading cause of cancer death among women in the US. Therapeutics employing novel mechanisms of action are therefore urgently needed. Oncolytic viruses (OVs) selectively infecting and replicating in cancer cells have recently attracted considerable interest as promising anti-cancer agents.
Tanja Fehm +3 more
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Virotherapies in Pancreatic Cancer
2017Oncolytic virotherapy represents a novel therapeutic strategy in the treatment of pancreatic cancer. Oncolytic viruses, including naturally occurring or genetically modified viruses, have the potential to selectively replicate in tumor cells and induce apoptosis without harming the surrounding normal tissue, thus representing an innovative and ...
Ramesh K. Ramanathan, Daniel H. Ahn
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