Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone
Advanced Science, EarlyView.In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman +15 more
wiley +1 more source
Research on the emotional generation mechanism and optimization pathways of traditional village landscapes in northeastern Hubei based on EEG measurements. [PDF]
Front PsycholLi Y, Yan X.
europepmc +1 more source
Isosteric Substitution Enables Rational Design of Two‐Dimensional Energetic Crystals
Advanced Science, EarlyView.Isosteric substitution transforms a classical nitro–amine motif into two‐dimensional aminofurazans with performance beyond TATB. ABSTRACT Two‐dimensional (2D) energetic crystals dissipate mechanical insult via interlayer slip, yet their molecular design space remains narrow.
Linyuan Wen +6 more
wiley +1 more source
IDeS + TRIZ: Sustainability Applied to DfAM for Polymer-Based Automotive Components. [PDF]
Polymers (Basel)Leon-Cardenas C +3 more
europepmc +1 more source
Energy‐Resolved Femtosecond Dynamics of Plasmon‐Induced Hole Injection at Au/GaN Heterointerfaces
Advanced Science, EarlyView.We reveal the spectral signature of ultrafast nonthermal hot‐hole transfer at plasmonic heterointerfaces, which reshapes hot‐carrier relaxation dynamics and significantly enhances hydrogen evolution, providing a mechanistic basis for optimizing hot‐carrier utilization in photocatalysis.
Yuying Gao +8 more
wiley +1 more source
Image-based Evaluation of Cutting Forces During Ultrasonic Cutting of Bone. [PDF]
Exp MechMarek A, Li X, Lucas M, Pierron F.
europepmc +1 more source
Advanced Science, EarlyView.Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong +21 more
wiley +1 more source
A professional training simulator for skill acquisition in ultrasound-guided lumbar facet syndrome intervention: design and educational evaluation. [PDF]
Front Digit HealthCurto B +5 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT The lithium plating reaction in graphite electrodes acts as a root cause for the accelerated degradation and the internal short circuits in lithium‐ion batteries. Here, an electrochemical model based on multi‐scale microstructural images was established to identify lithium plating‐stripping processes, thereby supporting the predictive outcomes
Heng Huang +9 more
wiley +1 more source
Bandwidth broadening in cavity-type sound-absorbing metamaterials via additional equivalent stiffness. [PDF]
Sci RepWang LB, Wu JH, Zhang JF.
europepmc +1 more source