Results 241 to 250 of about 18,745,540 (280)

A Unified Hierarchical Multiscale Fusion Framework for Drug–Target Affinity Prediction: From Benchmark Performance to Nanomolar Inhibitor Discovery

Advanced Science, EarlyView.
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu, Xiang Zhang, Haixia Feng, Yuquan Li, Xiaoqing Gong, Yong Liang, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Machine learning prediction of post-traumatic osteoarthritis based on three-dimensional printing-derived joint congruence biomechanics in ankle fractures. [PDF]

Front Med (Lausanne)
Wang X, Hu B, Chen W, Yang H, Cheng Y, Chen K.   +5 more
europepmc   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Imaging Earth's subsurface with thunderstorm-generated seismic waves. [PDF]

Sci Adv
Roth N, Kim D, Czarny R, Kim YC, Wauthier C, Zhu T.   +5 more
europepmc   +1 more source

High-Resolution Forward-Looking Imaging Method for FMCW Radar Based on Sparse Sampling. [PDF]

Sensors (Basel)
Zhao Q, Yan X, Zhang T, Hou Q, Liu Q, Wang J, Wang X.   +6 more
europepmc   +1 more source

Assessment of the Forces Developed During Orthodontic Treatment Using the Finite Element Method. [PDF]

Dent J (Basel)
Nardin MM, Brătoiu MR, Preoteasa CT, Vlăduțu DE, Popa DL, Done AE, Rauten AM, Mărășescu FI, Dăguci L, Mercuț V.   +9 more
europepmc   +1 more source

Mesoscopic Heterogeneous Modeling Method for Polyurethane-Solidified Ballast Bed Based on Virtual Ray Casting Algorithm. [PDF]

Materials (Basel)
Xu Y, Sheng Z, Zhang J, Han H, Ling X, Zhang X, Qie L.   +6 more
europepmc   +1 more source

Finite Element Model Updating for Rotating Machinery: Methods, Applications, and Future Directions-A Review. [PDF]

Sensors (Basel)
Park D, Moon J, Yoon J, Choi BK.
europepmc   +1 more source

Uncertainty Quantification of Finite Element Strain Predictions for a Nitinol Medical Device: Influence of Input Parameter Probability Distribution on Output Uncertainty. [PDF]

Cardiovasc Eng Technol
Carr IA, Aycock KI, Paranjape H, Bonsignore C, Weaver JD, Craven BA.   +5 more
europepmc   +1 more source