Results 51 to 60 of about 648,541 (281)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Virtual Element Method for 2D linear elastic fracture analysis

, 2018
This paper presents the Virtual Element Method (VEM) for the modeling of crack propagation in 2D within the context of linear elastic fracture mechanics (LEFM).
Nguyen-Thanh, Vien Minh, Nguyen-Xuan, Hung, Rabczuk, Timon, Wriggers, Peter, Zhuang, Xiaoying   +4 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A C⁰ Nonconforming Virtual Element Method for the Kirchhoff Plate Obstacle Problem

Axioms
This paper investigates a novel C0 nonconforming virtual element method (VEM) for solving the Kirchhoff plate obstacle problem, which is described by a fourth-order variational inequality (VI) of the first kind.
Bangmin Wu, Jiali Qiu
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

A virtual element method for transversely isotropic elasticity [PDF]

Computational Mechanics, 2019
This work studies the approximation of plane problems concerning transversely isotropic elasticity, using a low-order Virtual Element Method (VEM), with a focus on near-incompressibility and near-inextensibility. Additionally, both homogeneous problems, in which the plane of isotropy is fixed; and non-homogeneous problems, in which the fibre direction ...
B. D. Reddy, D. van Huyssteen
openaire   +3 more sources

Homogenization of composite materials reinforced with unidirectional fibres with complex curvilinear cross section: a virtual element approach

Mathematics in Engineering
The paper presents an augmented curvilinear virtual element method to determine homogenized in-plane shear material moduli of long-fibre reinforced composites in the framework of asymptotic homogenization method.
E. Artioli , G. Elefante, A. Sommariva, M. Vianello   +3 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Virtual element methods for Biot–Kirchhoff poroelasticity

Mathematics of Computation
This paper analyses conforming and nonconforming virtual element formulations of arbitrary polynomial degrees on general polygonal meshes for the coupling of solid and fluid phases in deformable porous plates. The governing equations consist of one fourth-order equation for the transverse displacement of the middle surface coupled with a second-order ...
Khot, Rekha, Mora, David, Ruiz-Baier, Ricardo   +2 more
openaire   +3 more sources

Virtual element approximations of the time-fractional nonlinear convection-diffusion equation on polygonal meshes

Mathematics in Engineering
We extend the Virtual Element Method to a two-dimensional unsteady nonlinear convection-diffusion equation characterized by a fractional-order derivative with respect to the time variable.
Zaffar Mehdi Dar, M. Arrutselvi, Chandru Muthusamy, Sundararajan Natarajan, Gianmarco Manzini   +4 more
doaj   +1 more source