Results 61 to 70 of about 651,142 (275)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Virtual element methods for Biot–Kirchhoff poroelasticity

Mathematics of Computation
This paper analyses conforming and nonconforming virtual element formulations of arbitrary polynomial degrees on general polygonal meshes for the coupling of solid and fluid phases in deformable porous plates. The governing equations consist of one fourth-order equation for the transverse displacement of the middle surface coupled with a second-order ...
Khot, Rekha, Mora, David, Ruiz-Baier, Ricardo   +2 more
openaire   +3 more sources

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

A Virtual Element Method for a (2+1)-Dimensional Wave Equation with Time-Fractional Dissipation on Polygonal Meshes

Fractal and Fractional
We propose a novel space-time discretization method for a time-fractional dissipative wave equation. The approach employs a structured framework in which a fully discrete formulation is produced by combining virtual elements for spatial discretization ...
Zaffar Mehdi Dar, Chandru Muthusamy, Higinio Ramos   +2 more
doaj   +1 more source

PEMBELAJARAN KIMIA BERBASIS KOOPERATIF THINK PAIR SHARE (TPS) DENGAN BERBANTUAN VIRTUAL LABORATORIUM UNTUK MENINGKATKAN HASIL BELAJAR SISWA

Jurnal Inovasi Pendidikan Kimia, 2021
Element Chemistry is one of the materials given to class XII students. Studying the chemical elements of the substance cause a sense of saturation because of the broad scope of the material and is memorized. To help and facilitate students learning in an
Kusumawati Dwiningsih, Bintang Benarivo Mangengke   +1 more
doaj   +1 more source

Veamy: an extensible object-oriented C++ library for the virtual element method

, 2018
This paper summarizes the development of Veamy, an object-oriented C++ library for the virtual element method (VEM) on general polygonal meshes, whose modular design is focused on its extensibility.
Alvarez, Catalina, Hitschfeld-Kahler, Nancy, Olate-Sanzana, Edgardo, Ortiz-Bernardin, Alejandro, Russo, Alessandro, Silva-Valenzuela, Rodrigo   +5 more
core   +1 more source

Orthogonal Polynomial Bases in the Mixed Virtual Element Method

SSRN Electronic Journal, 2022
AbstractThe use of orthonormal polynomial bases has been found to be efficient in preventing ill‐conditioning of the system matrix in the primal formulation of Virtual Element Methods (VEM) for high values of polynomial degree and in presence of badly‐shaped polygons.
Berrone S., Scialo S., Teora G.
openaire   +3 more sources

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

A Fractional PDE-Based Model for Nerve Impulse Transport Solved Using a Conforming Virtual Element Method: Application to Prosthetic Implants

Axioms
The main objective of this study is to present a fundamental mathematical model for nerve impulse transport, based on the underlying physical phenomena, with a straightforward application in describing the functionality of prosthetic devices.
Zaffar Mehdi Dar, Chandru Muthusamy, Higinio Ramos   +2 more
doaj   +1 more source

An Efficient Boundary-Type Meshless Computational Approach for the Axial Compression on the Part Boundary of the Circular Shaft (Brazilian Test)

Applied Sciences, 2022
An efficient boundary-type meshless computational approach, namely, the virtual boundary meshless Galerkin method (VBMGM), as the partial differential equation on the weak term is shown for solving the axial compression on the part boundary of the ...
Jing Ling, Hongying Wang, Hongzhong Mou
doaj   +1 more source