Results 61 to 70 of about 9,294,963 (257)

Improving virtual reality exposure therapy with open access and overexposure: a single 30-minute session of overexposure therapy reduces public speaking anxiety

Frontiers in Virtual Reality
Public speaking anxiety is a prevalent issue with significant negative impacts. While virtual reality exposure therapy is an effective treatment, it currently has significant limitations.
Chris Macdonald
doaj   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

The Effectiveness of Reality Therapy Training on Marital Burnout in Couple with Marital Conflicts

Taḥqīqāt-i ̒Ulūm-i Raftārī, 2020
Aim and Background: Burnout in couples is a gradual and rarely sudden process in which intimacy and love are gradually faded and general fatigue becomes evident.
Maryam Jafarimanesh, Kianoosh Zahrakar, Davood Taghvaei, Zabih Pirani   +3 more
doaj  

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Fear of falling: efficacy of virtual reality associated with serious games in elderly people

Neuropsychiatric Disease and Treatment, 2016
Fanny Levy,1 Pierre Leboucher,2 Gilles Rautureau,2 Odile Komano,2 Bruno Millet,1 Roland Jouvent1 1Department of Adults Psychiatry, 2PRISME-Virtual Reality, ICM-A- IHU, UPMC UMR_S 975, Inserm U 1127, CNRS UMR 7225, GH Pitié-Salpêtri ...
Levy F, Leboucher P, Rautureau G, Komano O, Millet B, Jouvent R   +5 more
doaj  

Virtual Reality Exposure Therapy

, 2014
Virtual reality exposure therapy (VRET) is based on the assumption that anxiety subsides through a process of habituation after a person has been exposed to a fearful situation for a prolonged period of time.
Meyerbröker, K., Katharina Meyerbröker
core   +1 more source

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

Advanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok, Laura Činč Ćurić, Jernej Vajda, Silvia Schauer, Martin Wagner, Rudolf Stauber, Carolin Lackner, Karl Kashofer, Markus Plass, Giovanny Rodriguez Blanco, Ian R. Wanless, Uroš Maver, Katrin Panzitt, Boštjan Vihar   +13 more
wiley   +1 more source

Remapped physical-virtual interfaces with bimanual haptic retargeting

, 2019
This paper proposes a novel interface for virtual reality in which physical interface components are mapped to multiple virtual counterparts using haptic retargeting illusions.
Matthews, B.J., Von Itzstein, S., Smith, R.T., Thomas, B.H.   +3 more
core   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Anxiety activating virtual environments for investigating social phobias [PDF]

Social phobia has become one of the commonest manifestations of fear in any society. This fear is often accompanied by major depression or social disabilities.
Kwon, Remi Jounghuem
core