Results 111 to 120 of about 323,103 (298)

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

The case for emulating insect brains using anatomical "wiring diagrams" equipped with biophysical models of neuronal activity

, 2018
Developing whole-brain emulation (WBE) technology would provide immense benefits across neuroscience, biomedicine, artificial intelligence, and robotics.
Collins, Logan Thrasher
core   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

Advanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao, Ata Golparvar, Mohammad Javad Bathaei, Filipe Arroyo Cardoso, Clementine M. Boutry   +4 more
wiley   +1 more source

Utility of three-dimensional virtual reconstruction for robotic-assisted partial nephrectomy using the IRIS™. [PDF]

Asian J Urol, 2023
Mehrazin R, Razdan S.
europepmc   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

Retracted: Public Art and Space Environment Design Using Genetic Algorithm-Guided 3D Virtual Reconstruction. [PDF]

J Environ Public Health, 2023
Environmental And Public Health JO.
europepmc   +1 more source

Surface Reconstruction and Evolution from Multiple Views [PDF]

, 2010
Applications like 3D Telepresence necessitate faithful 3D surface reconstruction of the object and 3D data compression in both spatial and temporal domains. This makes us feel immersed in virtual environments there by making 3D Telepresence a powerful
Jana, Soumya, M, Sudhakar
core  

Virtually Reconstructing Bernhard Heine’s Osteotome

Heritage
The osteotome was a hand-cranked medical chainsaw designed in 1830 by the German surgeon Bernhard Heine. Before Heine, surgeons used crude, manual tools, such as hammers, chisels, and handsaws. The osteotome was among the first mechanical tools used in orthopedic surgery, and it preceded the later use of the motorized chainsaw for woodcutting.
John LaRocco, Eric Zachariah
openaire   +2 more sources

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source

Virtual reconstruction of midfacial bone defect based on generative adversarial network. [PDF]

Head Face Med, 2022
Xiong YT, Zeng W, Xu L, Guo JX, Liu C, Chen JT, Du XY, Tang W.   +7 more
europepmc   +1 more source