Results 101 to 110 of about 40,063 (291)

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Enhancing Li‐S Battery Performance Through Low‐Concentration Electrolytes with Organic Se/Te Co‐Additives to Address Solubility and Kinetic Challenges

Advanced Science, EarlyView.
This work presents a low‐concentration electrolyte enabled by hybrid organic Se/Te additives (DPDSe/DPDTe) that restructures solvation, boosts polysulfide dissolution, and provides dual‐site synergistic catalysis, delivering high capacity and stable cycling in Li–S coin and pouch cells, supporting high‐energy, high‐power operation.
Ruihua Li, Haiwei Wu, Hairu Wei, Wenhao Jia, Frederik Bettels, Leon Schenk, Zhihua Lin, Hanbin Liu, Guodong Liu, Zhijian Li, Lin Zhang   +10 more
wiley   +1 more source

Feminist Virtue Ethics [PDF]

, 2015
I evaluate the ways in which feminist philosophy intersects with the major strands of contemporary virtue ethics, especially neo-Aristotelian and sentimentalist versions of virtue ethics.
Stohr, Karen
core   +1 more source

Virtue Ethics: The Misleading Category

Areté, 1999
La ética de la virtud es frecuentemente considerada una categoría singular de la teoría ética, y una rival del kantismo y del utilitarismo. Considero que es un error, puesto que tanto kantianos como utilitaristas pueden tener, y tienen, un interés en las
Martha Nussbaum
doaj  

In Defence of Nudging from a Virtue Ethics Perspective

Conatus - Journal of Philosophy
Nudging is typically understood as a design intended to influence the behaviour or choices of decision-makers to promote their own or other stakeholders’ welfare by steering choices in beneficial directions without restricting their freedom of choice ...
Ritesh Bansal, Joby Varghese
doaj   +1 more source

Usulan a. Macintyre Kembali ke Etika Keutamaan : Sebuah Solusi atau Nostalgia Belaka?

Kanz Philosophia: A Journal for Islamic Philosophy and Mysticism, 2014
Abtract : As an alternative to the impasse of the modern-enlightenment project in ethics, Alasdair MacIntyre suggests to recourse to virtue-ethics.
J. Sudarminta
doaj   +1 more source

Virtue Ethics in a Value-Driven World: Pareto Meets PROMIS. [PDF]

Clin Orthop Relat Res, 2023
Humbyrd CJ.
europepmc   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

Murdoch’s Platonistic virtue ethics

, 2014
In this paper I develop a thesis about normative ethics that we might call Platonistic virtue ethics (PVE): Good agency in the truest and fullest sense presupposes the contemplation of the Form of the Good.
Chappell, Timothy
core  

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source