Results 81 to 90 of about 863,901 (283)

Schizophrenia and the Virtues of Self-Effacement

open access: yesLes Ateliers de l’Ethique, 2016
Michael Stocker’s “The Schizophrenia of Modern Ethical Theories” attacks versions of consequentialism and deontological ethics on the grounds that they are self-effacing.
La Trobe University
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Two Objections to Virtue Ethics [PDF]

open access: yes, 2016
This paper explores two objections to virtue ethics: the self-effacing objection, which holds that virtue ethics is problematic insofar as it presents a justification for the exercise of the virtues that cannot be appealed to as an agent’s motive for ...
Besser-Jones, Lorraine
core  

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

open access: yesAdvanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang   +10 more
wiley   +1 more source

Filial Piety and Business Ethics: A Confucian Reflection

open access: yes, 2020
This volume examines the breadth and depth of virtue ethics and aims to counter the virtue ethics amnesia that both afflicts general moral philosophy and affects business and management ...
Mondejar, R, Kim, R, Chu, C
core  

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

open access: yesAdvanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo   +10 more
wiley   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

open access: yesAdvanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou   +9 more
wiley   +1 more source

Feminist Virtue Ethics [PDF]

open access: yes, 2015
I evaluate the ways in which feminist philosophy intersects with the major strands of contemporary virtue ethics, especially neo-Aristotelian and sentimentalist versions of virtue ethics.
Stohr, Karen
core   +3 more sources

Heideggerian Environmental Virtue Ethics

open access: yes, 2010
Environmental ethics is apparently caught in a dilemma. We believe in human species partiality as a way of making sense of many of our practices. However as part of our commitment to impartialism in ethics, we arguably should extend the principle of ...
Swanton, CH
core   +1 more source

Application and Single‐Cell Regulation Mechanism of Engineered EVs Combined With 4D‐Printed Hydrogel for Infected Burn Repair

open access: yesAdvanced Science, EarlyView.
4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang   +19 more
wiley   +1 more source

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