Results 61 to 70 of about 28,035 (244)

Towards Computer Simulations of Virtue Ethics

open access: yesOpen Philosophy, 2019
This article presents two approaches for computer simulations of virtue ethics in the context of agent-based modeling, a simple way and a complex way.
Lasquety-Reyes Jeremiah A.
doaj   +1 more source

Virtue and vice in environmental discourse

open access: yesStudia Ecologiae et Bioethicae, 2013
For effective environmental protection, the necessary tools are not only the external ones in the form of commands, and legal or economic instruments.
Dominika Dzwonkowska
doaj   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan   +17 more
wiley   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li   +15 more
wiley   +1 more source

Ethics as a political alternative to the control devices

open access: yesFilosofia Unisinos, 2021
The control societies reduced the person to a struture proceeding to obtain efficient an the institutional objetives. Their control methods make flexivel subjetivities. One alternative to the control dispositives is to ransom the ethics so a praxis that
Castor M. M. Bartolomé Ruiz
doaj  

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

open access: yesAdvanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He   +10 more
wiley   +1 more source

Ethics of Duty vs. Ethics of Virtue in Teacher Training

open access: yesPaedagogia Christiana, 2011
Given the assumption that a modern teacher’s role cannot just be narrowed down to being an instructor, but that he should also carry out the role of a form tutor providing all necessary care, advice, assistance and support for a maturing person, the ...
Jarosław Horowski
doaj   +1 more source

A Protein‐Centric Strategy Coupled with Match‐Between‐Run Glycoproteomics Enables Discovery of Robust Site‐Specific Glycan Biomarkers for Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
In this study, a highly robust N‐glycoproteomics (HRN) platform with a newly developed match‐between‐run scheme is used for biomarker discovery. This study proposes a protein‐centric strategy to prioritize proteins susceptible to aberrant glycosylation.
Lei Liu   +15 more
wiley   +1 more source

John Doris' Excellence Adventure

open access: yesRevista de Filosofia Antiga, 2018
: In his book Lack of Character (2002 Cambridge University Press) John Doris argues that both virtue ethics and common sense or folk psychology are committed to the claim that the attribution of character to persons is predictive, explanatory, and ...
Carrie Swanson
doaj   +1 more source

Cohort‐Scale Spatial Autocorrelation for Tumor Prediction in Mid‐Infrared Pathology and Spatial Biomarker Discovery Using MALDI Imaging Lipidomics

open access: yesAdvanced Science, EarlyView.
Computational annotation of various tissue types in heterogeneous samples such as colorectal cancer liver metastasis (CRLM) using spatial autocorrelation analysis on non‐destructive mid‐infrared (MIR) imaging data enabled correlative multimodal mass spectrometry imaging (MSI) for spatial investigation of lipid tumor marker candidates. The method can be
Miriam F. Rittel   +12 more
wiley   +1 more source

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