Results 81 to 90 of about 359,484 (337)
Advanced Science, EarlyView.The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu +16 more
wiley +1 more source
The Core Virtue of Christian Librarianship [PDF]
, 2002 Christian librarians should derive their professional ethics from methodical exegesis of the Bible. The New Testament\u27s most salient ethical statements center on love-for God, neighbor, and fellow believers.
Smith, Gregory A.
core +2 more sources
Advanced Science, EarlyView.This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng +15 more
wiley +1 more source
Wady środowiskowe jako etyczne i antropologiczne źródła kryzysu środowiskowego
Studia Ecologiae et Bioethicae, 2014 The root of the environmental crisis is not only the failure to recognize the intrinsic value of the non-human world, but it can also be perceived as a failure in moral excellence and in the cultivation of virtue.
Dominika Dzwonkowska
doaj +1 more source
Two Objections to Virtue Ethics [PDF]
, 2016 This paper explores two objections to virtue ethics: the self-effacing objection, which holds that virtue ethics is problematic insofar as it presents a justification for the exercise of the virtues that cannot be appealed to as an agent’s motive for ...
Besser-Jones, Lorraine
core +1 more source
The Importance of Roles in the Skill Analogy [PDF]
, 2020 This paper argues for a reinterpretation of the skill analogy in virtue ethics. It argues that the skill analogy should not be understood as proposing that being virtuous is analogous to possessing a practical skill but, rather, as proposing that being ...
Dougherty, Matt
core
Vulnerabilities and responsibilities: dealing with monsters in computer security [PDF]
, 2009 Purpose – The purpose of this paper is to analyze information security assessment in terms of cultural categories and virtue ethics, in order to explain the cultural origin of certain types of security vulnerabilities, as well as to enable a proactive ...
Consoli, L., Pieters, W.
core +4 more sources
Advanced Science, EarlyView.In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou +13 more
wiley +1 more source
Virtue and vice in environmental discourse
Studia Ecologiae et Bioethicae, 2013 For effective environmental protection, the necessary tools are not only the external ones in the form of commands, and legal or economic instruments.
Dominika Dzwonkowska
doaj +1 more source
PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites
Advanced Science, EarlyView.This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang +13 more
wiley +1 more source