Results 111 to 120 of about 861,199 (358)

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo [PDF]

open access: yes, 2016
Burkholderia cenocepacia, an opportunistic respiratory pathogen particularly relevant for cystic fibrosis patients, is difficult to eradicate due to its high level of resistance to most clinically relevant antimicrobials.
Azzalin, Alberto   +11 more
core   +2 more sources

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

open access: yesToxins, 2019
Helicobacter pylori colonizes the gastric epithelial cells of at least half of the world’s population, and it is the strongest risk factor for developing gastric complications like chronic gastritis, ulcer diseases, and gastric cancer.
S. Ansari, Y. Yamaoka
semanticscholar   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

open access: yesAdvanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak   +2 more
wiley   +1 more source

Clinical factors associated with peripherally inserted central catheters (PICC) related bloodstream infections: a single centre retrospective cohort

open access: yesAntimicrobial Resistance and Infection Control, 2023
Background Despite their spread in daily practice, few data is available on clinical factors associated with peripherally inserted central catheter (PICC)-related bloodstream infections (PR-BSI). We aimed to assess the PR-BSI incidence, microbiology, and
Koko Barrigah-Benissan   +8 more
doaj   +1 more source

Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors

open access: yesApplied Microbiology and Biotechnology, 2019
At present, anti-virulence drugs are being considered as potential therapeutic alternatives and/or adjuvants to currently failing antibiotics. These drugs do not kill bacteria but inhibit virulence factors essential for establishing infection and ...
S. A. S. Ahmed   +5 more
semanticscholar   +1 more source

Trait‐Based Life History Strategies Shape Bacterial Niche Breadth

open access: yesAdvanced Science, EarlyView.
This study investigates bacterial niche breadth through a large‐scale soil survey and over 2000 bacterial genomes. It identifies key life‐history traits—growth, competition, stress tolerance, resource acquisition, and dispersal—that correlate with niche breadth.
Ziheng Peng   +8 more
wiley   +1 more source

Wheat microbiome bacteria can reduce virulence of a plant pathogenic fungus by altering histone acetylation

open access: yesNature Communications, 2018
Interactions between bacteria and fungi have great environmental, medical, and agricultural importance, but the molecular mechanisms are largely unknown.
Yun Chen   +6 more
semanticscholar   +1 more source

ROS‐Driven Nanoventilator for MRSA‐Induced Acute Lung Injury Treatment via In Situ Oxygen Supply, Anti‐Inflammation and Immunomodulation

open access: yesAdvanced Science, EarlyView.
A ROS‐driven in situ oxygen supply nanoventilator based on enzyme nanocapsule can convert ROS into O2 through enzyme cascade reaction between SOD and CAT to relieve lung hypoxia, and kill MRSA by releasing vancomycin, which effectively reduces HIF‐1α expression and balances pro‐inflammatory/anti‐inflammatory macrophages ratio, thereby reducing the ...
Zheng Luo   +7 more
wiley   +1 more source

Adherence to and Invasion of Human Intestinal Cells by Arcobacter Species and Their Virulence Genotypes [PDF]

open access: yes, 2013
The genus Arcobacter is composed of 17 species which have been isolated from various sources. Of particular interest are A. butzleri, A. cryaerophilus, and A.
Alkeskas, A   +4 more
core   +1 more source

From De Novo Conceived Small Molecules to Multifunctional Supramolecular Nanoparticles: Dual Biofilm and T3SS Intervention, Enhanced Foliar Affinity, and Effective Rice Disease Control

open access: yesAdvanced Science, EarlyView.
From de novo engineered bioactive molecules BtP27 to the multifunctional supramolecular material BtP27@β‐CD with a sunflower‐shaped morphology: its pragmatic applications in augmenting foliar affinity, disrupting biofilms and T3SS, and managing rice pathologies. Abstract Conventional antimicrobials typically exhibit suboptimal deposition on rice leaves,
Xianfu Mu   +6 more
wiley   +1 more source

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