Results 201 to 210 of about 861,199 (358)

Antibacterial effects of natural compounds on biofilm formation of Streptococcus mutans

open access: yesClinical and Experimental Dental Research, Volume 8, Issue 6, Page 1426-1433, December 2022., 2022
Abstract Streptococcus mutans is the main cariogenic pathogen in the oral cavity, considered to contribute toward oral diseases. S. mutans is predominantly entrapped in plaque biofilms. Objectives In this study, we surveyed the antibacterial activity of natural compounds in terms of the biofilm production of S. mutans. Material and Methods We extracted
Farideh Kamarehei   +2 more
wiley   +1 more source

Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes

open access: yesAngewandte Chemie International Edition, Accepted Article.
Phosphodiester groups occur ubiquitously in nature, e.g. in nucleic acids or in cyclic (di‐)nucleotides important for signal transduction. Proteins often use polar or positively charged amino acids to interact with the negatively charged phosphodiester groups via hydrogen bonds and salt bridges.
Jens Wöhnert   +5 more
wiley   +1 more source

Clinical and laboratory profile and outcomes of hospitalized COVID‐19 patients with type 2 diabetes mellitus in Ghana – A single‐center study

open access: yesEndocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
This study describes the clinical and laboratory profile and outcomes of hospitalized COVID‐19 patients with type 2 diabetes mellitus (DM) in Ghana. Out of 175 patients (mean age 55.9+/−18.3 years) 64 (36.6%) had DM. Compared to non‐diabetics, DM patients were older (61.1? 12.8 vs. 53.0?
Yasmine Oladele Hardy   +13 more
wiley   +1 more source

A Single‐Molecule Liposome Assay for Membrane Permeabilisation

open access: yesAngewandte Chemie International Edition, Accepted Article.
Cell membrane disruption is associated with numerous diseases and underlies the activity of various antimicrobial agents. The rapid screening of compounds capable of disrupting or permeabilising biological membranes is essential to the search for new therapeutic drugs.
Krzysztof Marek Bąk   +9 more
wiley   +1 more source

Novel Approaches To Design Glycan‐Based Antibacterial Inhibitors

open access: yesEuropean Journal of Organic Chemistry, Volume 26, Issue 1, January 2, 2023., 2023
Sweet and sticky: This review describes recent advances in the synthesis and application of homo‐and heterovalent glycan‐scaffolds as potential candidates for efficient bacteria lectin inhibition. To study and address the many complex molecular mechanisms involved in multivalent lectin binding events, novel glycoconjugate designs and fine‐tunable ...
Sandra Behren, Ulrika Westerlind
wiley   +1 more source

A Coupled Two-Tier Mathematical Transmission Model to Explore Virulence Evolution in Vector-Borne Diseases [PDF]

open access: yesarXiv
The emergence or adaptation of pathogens may lead to epidemics, highlighting the need for a thorough understanding of pathogen evolution. The tradeoff hypothesis suggests that virulence evolves to reach an optimal transmission intensity relative to the mortality caused by the disease.
arxiv  

Functional activity of peptide ion channels in tethered bilayer lipid membranes: Review

open access: yesElectrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022
Abstract Ion transport across biomembranes plays a major role in living cells. This fundamental function is normally carried out by molecules with both a hydrophobic and a hydrophilic side (amphiphilic molecules), which aggregate within the membrane forming a hydrophilic pore (the ion channel) permitting the selective translocation of permeant ions ...
Rolando Guidelli, Lucia Becucci
wiley   +1 more source

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