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The Epistemology of Bacterial Virulence Factor Characterization
MicroorganismsThe field of microbial pathogenesis seeks to identify the agents and mechanisms responsible for disease causation. Since Robert Koch introduced postulates that were used to guide the characterization of microbial pathogens, technological advances have ...
Matthew Jackson +2 more
doaj +1 more source
PLoS Pathogens, 2009 Bacteria use a variety of secreted virulence factors to manipulate host cells, thereby causing significant morbidity and mortality. We report a mechanism for the long-distance delivery of multiple bacterial virulence factors, simultaneously and directly ...
Jennifer M Bomberger +5 more
doaj +1 more source
A Data-Validated Host-Parasite Model for Infectious Disease Outbreaks [PDF]
, 2019 The use of model experimental systems and mathematical models is important to further understanding of infectious disease dynamics and strategize disease mitigation. Gyrodactylids are helminth ectoparasites of teleost fish which have many dynamical characteristics of microparasites but offer the advantage that they can be quantified and tracked over ...
arxiv +1 more source
Parasitologists United Journal, 2020 Parasites developed several strategies for their survival and host tissue invasion. Helminths express potent molecules mainly for immunomodulation, which is why they stay in their hosts for years.
S. Abaza
semanticscholar +1 more source
Virulence Factors of Erwinia amylovora: A Review [PDF]
International Journal of Molecular Sciences, 2015 Erwinia amylovora, a Gram negative bacteria of the Enterobacteriaceae family, is the causal agent of fire blight, a devastating plant disease affecting a wide range of host species within Rosaceae and a major global threat to commercial apple and pear production.
Núria Piqué +3 more
openaire +4 more sources
Advanced Theory and Simulations, EarlyView.The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak +2 more
wiley +1 more source
Informatics in Medicine Unlocked, 2023 Background: Vibrio cholerae leads to severe acute watery diarrhea with a high mortality rate; owing to several virulence factors, especially the cholera toxin.
Narjes Noori Goodarzi +3 more
doaj
Virulence factors of theMycobacterium tuberculosiscomplex [PDF]
Virulence, 2013 The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages.
Forrellad, Marina Andrea +7 more
openaire +5 more sources
Advanced Science, EarlyView.A ROS‐driven in situ oxygen supply nanoventilator based on enzyme nanocapsule can convert ROS into O2 through enzyme cascade reaction between SOD and CAT to relieve lung hypoxia, and kill MRSA by releasing vancomycin, which effectively reduces HIF‐1α expression and balances pro‐inflammatory/anti‐inflammatory macrophages ratio, thereby reducing the ...
Zheng Luo +7 more
wiley +1 more source
The impacts of H. pylori virulence factors on the development of gastroduodenal diseases
Journal of Biomedical Sciences, 2018 Although most H. pylori infectors are asymptomatic, some may develop serious disease, such as gastric adenocarcinoma, gastric high-grade B cell lymphoma and peptic ulcer disease.
Wei-Lun Chang, Yi-Chun Yeh, B. Sheu
semanticscholar +1 more source