Results 101 to 110 of about 7,750,643 (307)

Determination of virulence factors and biofilm formation among isolates of vulvovaginal candidiasis

Journal of Medical Sciences, 2016
Context: Under morphogenesis-inducing conditions, Candida spp. begins to undergo yeast-to-hypha switch. This shift from commensal to pathogenic state is dependent on several virulence factors. Aim: To find out whether the isolated Candida spp.
Tapan Majumdar, Jhinuk Basu Mullick, Raunak Bir, Jayanta Roy, Samir Kumar Sil   +4 more
doaj   +1 more source

Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis. [PDF]

, 2015
Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S.
Schultsz, C, Langford, P.R., Maglennon, Gareth A, Campbell, J., Wang, J., Chieu, T.T.B., Tran, TBC, Wren, B.W., Hoa, N.T., Tucker, Alexander W, Corander, Jukka, Corander, J., Ngo Thi, H, Schultsz, Constance, Valimaki, N, Wren, BW, Schultsz, C., Farrar, Jeremy, Holden, M T G, Wren, B W, Baker, S., Peters, Sarah E., Wang, Jinhong, Jombart, T., Maskell, DJ, Cuccui, Jon, Vehkala, Minna, Chaudhuri, RR, Chieu, TTB, Campbell, James, Rycroft, Andrew N, Campbell, J, Weinert, Lucy A, Wren, Brendan W, BRaDP1T Consortium, Chaudhuri, R R, Wang, J, Chaudhuri, Roy R, Terra, Vanessa, Chieu, Tran Thi Bich, Baig, Abiyad, Rycroft, A N, Nguyen, VVC, Howell, Kate J, Parkhill, Julian, Maskell, D J, Bentley, S D, Chaudhuri, R.R., Chau, N.V.V., Howell, Kate J., Baker, Stephen, Valimaki, N., Jombart, Thibaut, Baker, S, Ngo Thi Hoa, Tucker, AW, Weinert, LA, Ngo, TH, Baig, A., Peters, S.E., Rycroft, A.N., Tucker, A.W., Holden, Matthew T G, Tucker, Alexander W., Chau, Nguyen Van Vinh, Howell, K.J., Peters, SE, Vehkala, M, Parkhill, J, Matthews, Dominic, Vehkala, M., Peters, S E, Bentley, Stephen D, Harris, D., Langford, PR, Chaudhuri, Roy R., Bentley, Stephen D., Holden, Matthew T. G., Tran Thi Bich Chieu, Nguyen, Van Vinh Chau, Baig, A, Farrar, J, Corander, J, Li, Yanwen, Langford, Paul R, Holden, M.T.G., Weinert, Lucy A., Bosse, Janine T, Jombart, T, Välimäki, Niko, Bentley, S.D., Holden, MTG, Tran, Thi Bich Chieu, Maskell, Duncan J, Hoa, NT, Rycroft, Andrew N., Rycroft, AN, Tucker, A W, Maskell, Duncan J., Langford, Paul R., Bentley, SD, Peters, Sarah E, Holden, Matthew TG, Howell, K J, Farrar, J., Parkhill, J., Wren, Brendan W., Weinert, L.A., Nguyen Van Vinh Chau, Maskell, D.J., BRaDP1T Consortium,, Hoa, Ngo Thi, Van Vinh Chau, Nguyen, Weinert, L A, Howell, KJ, Nguyen Van Vinh, C, Harris, D, Langford, P R, Van Vinh Chau, N, Harris, David, Tran Thi Bich, C, Vaelimaeki, N   +121 more
core   +6 more sources

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Evolution of malaria virulence in cross-generation transmission through selective immune pressure [PDF]

, 2007
Theoretical arguments and some mathematical models of host-parasite coevolution (e.g. [1- 6]) suggest host immunity as the driving source for the evolution of parasite virulence.
David E. Gurarie
core  

Phenotypic Characterization of Enzymatic and Non-enzymatic Virulence Factors in Etiopathogenesis and Evolution of Drug Resistance among Dermatophytes

, 2020
The virulence factors of dermatophytes play a vital role in the etio-pathogenesis and emergence of drug resistance. Regular surveillance is essential for constant monitoring of association of virulence factors in the emergence of drug resistant isolates ...
R. Prabha, M. Rajesh, Shanmuga Priya C
core   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Inhibition of bacterial virulence factors as a method of treating bacterial pneumonia

Zdorovʹe Rebenka, 2018
Incremental increase in the number of antibiotic-resistant bacterial strains in the etiologic structure of pneumonia and reduced potential of antibiotic therapy increase the importance of drugs in the treatment of pneumonia, which are aimed at ...
А.Е. Abaturov, Т.А. Kryuchko
doaj   +1 more source

When is a bacterial “virulence factor” really virulent? [PDF]

, 2016
ABSTRACT Bacterial traits that contribute to disease are termed ‘virulence factors’ and there is much interest in therapeutic approaches that disrupt such traits. However, ecological theory predicts disease severity to be multifactorial and context dependent, which might complicate our efforts to identify the most ...
Granato, Elisa T., Harrison, Freya, Kümmerli, Rolf, Ross-Gillespie, Adin   +3 more
openaire   +1 more source

Virulence Factors and Carbapenem-Resistance Mechanisms in Hypervirulent Klebsiella Pneumoniae [PDF]

Yiqun Liao,1 Junjie Gong,1 Xiaoliang Yuan,2 Xiaoling Wang,1 Yuanhong Huang,3 Xiaohong Chen1 1Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, People’s Republic of China; 2Department of Respiratory ...
Liao Y, Huang Y, Wang X, Chen X, Gong J, Yuan X   +5 more
core  

Aggregatibacter actinomycetemcomitans : virulence of its leukotoxin and association with aggressive periodontitis

, 2015
Periodontitis is an infection-induced inflammatory disease that causes loss of the tooth supporting tissues. Much focus has been put on comparison of the microbial biofilm in the healthy periodontium with the diseased one.
Höglund Åberg, Carola,, Johansson, Anders,, Kelk, Peyman,   +2 more
core   +1 more source