Results 101 to 110 of about 246,136 (261)
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching
Angewandte Chemie, EarlyView.Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Bengt H. Gless +5 more
wiley +2 more sources
Unveiling the hidden arsenal: new insights into Proteus mirabilis virulence in UTIs
Frontiers in Cellular and Infection MicrobiologyProteus mirabilis is a Gram-negative bacterium commonly found in urinary tract infections (UTIs) and catheter-associated urinary tract infections (CAUTIs).
Aoyu Yang, Yuchong Tian, Xiancheng Li
doaj +1 more source
A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing
Advanced Science, EarlyView.We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster +13 more
wiley +2 more sources
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew +8 more
wiley +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun +6 more
wiley +1 more source
Refining a preclinical model of viral myocarditis in accordance with biotech standards
Animal Models and Experimental Medicine, EarlyView.This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen +9 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Intermittent catheter use can damage the urinary tract and predispose to infection. We deployed a complex human urothelial model to investigate. Catheter contact induced compressive and shear stress causing umbrella cell disruption, reduced barrier function, inflammation and increased cell adhesion to the catheter surface.
Nazila V. Jafari, Jennifer L. Rohn
wiley +1 more source