Results 221 to 230 of about 64,077 (268)

In search of tuberculosis virulence genes

Trends in Microbiology, 1996
The identity of the virulence genes that enable tuberculosis organisms to survive in macrophages and to induce the features of tuberculosis remains largely unknown. Numerous putative virulence genes have been identified, but so far there is only conclusive evidence for the role of two genes, KatG and rpoV, in virulence.
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CRISPR Gene Editing of a Virulent Bacteriophage

Cold Spring Harbor Protocols, 2023
Genome editing by site-directed mutagenesis is an important tool in biological research. CRISPR gene editing is the latest such tool developed, and one that is widely applicable to study organisms from all kingdoms of life. Here, I introduce a method for making site-directed, defined mutations in a virulent bacteriophage (a bacterial virus) using ...
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Defining Virulence Genes in the Dimorphic Fungi

Annual Review of Microbiology, 2006
Most dimorphic fungal pathogens cause respiratory disease in mammals and must therefore possess virulence mechanisms to combat and overcome host pulmonary defenses. Over the past decade, advances in genetic tools have made it possible to investigate the basis of dimorphic fungal pathogenesis at the molecular level. Gene disruptions and RNA interference
Chad A, Rappleye, William E, Goldman
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Genes controlling retroviral virulence

1997
Publisher Summary Retroviruses under normal circumstances infect cells and yet inflict relatively little damage to the infected cell. The cell, however, remains infected for the lifespan of that cell or any daughter cells derived from that infected cell.
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Molecular analysis of spv virulence genes of the salmonella virulence plasmids

Molecular Microbiology, 1993
SummaryGenes on an 8 kb region common to the virulence plasmids of several serovars of Salmonella are sufficient to replace the entire plasmid in enabling systemic infection in animal models. This virulence region encompasses five genes which previously have been designated with different names from each investigating laboratory.
P A, Gulig, H, Danbara, D G, Guiney, A J, Lax, F, Norel, M, Rhen   +5 more
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Virulence Gene Regulation in Shigella

EcoSal Plus, 2004
Shigella species are the causative agents of bacillary dysentery in humans, an invasive disease in which the bacteria enter the cells of the epithelial layer of the large intestine, causing extensive tissue damage and inflammation. They rely on a plasmid-encoded type III secretion system (TTSS) to cause disease; this system and
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Expression of Virulence Genes in Candida Albicans

2005
The analysis of virulence gene expression patterns during infection gives insights into regulatory adaptation mechanisms of microbial pathogens in various host niches.The establishment of an in vivo expression technology for C. albicans allows us to investigate at which stage of an infection virulence genes might play a role in the host-pathogen ...
P, Staib, M, Kretschmar, T, Nichterlein, G, Köhler, J, Morschhäuser   +4 more
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VIRULENCE GENES OFCLOSTRIDIUM PERFRINGENS

Annual Review of Microbiology, 1998
▪ Abstract  Clostridium perfringens causes human gas gangrene and food poisoning as well as several enterotoxemic diseases of animals. The organism is characterized by its ability to produce numerous extracellular toxins including α-toxin or phospholipase C, θ-toxin or perfringolysin O, κ-toxin or collagenase, as well as a sporulation-associated ...
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Mapping Arenavirus Genes Causing Virulence

1987
The reassortment of genetic information from RNA viruses with segmented genomes, i. e., Arenaviridae, Bunyaviridae, Orthomyxoviridae, and Reoviridae families, can occur within cells infected by two different viral strains from the same family (COmpans etal. 1981; FIelds and GReene 1982; WEbster etal. 1982; Palese 1984).
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Bacterial Virulence Gene Regulation: An Evolutionary Perspective

Annual Review of Microbiology, 2000
▪ Abstract  Coevolution between bacteria and their plant or animal hosts determines characteristics of the interaction, the bacterial virulence genes involved, and the regulatory systems controlling expression of virulence genes. The long-standing association between Salmonellae and their animal hosts has resulted in the acquisition by Salmonella ...
P A, Cotter, V J, DiRita
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