Results 301 to 310 of about 5,329,833 (353)

Genes controlling retroviral virulence

1997
Publisher Summary Retroviruses under normal circumstances infect cells and yet inflict relatively little damage to the infected cell. The cell, however, remains infected for the lifespan of that cell or any daughter cells derived from that infected cell.
openaire   +2 more sources

In search of tuberculosis virulence genes

Trends in Microbiology, 1996
The identity of the virulence genes that enable tuberculosis organisms to survive in macrophages and to induce the features of tuberculosis remains largely unknown. Numerous putative virulence genes have been identified, but so far there is only conclusive evidence for the role of two genes, KatG and rpoV, in virulence.
openaire   +2 more sources

Bacterial Virulence Gene Regulation: An Evolutionary Perspective

Annual Review of Microbiology, 2000
▪ Abstract  Coevolution between bacteria and their plant or animal hosts determines characteristics of the interaction, the bacterial virulence genes involved, and the regulatory systems controlling expression of virulence genes. The long-standing association between Salmonellae and their animal hosts has resulted in the acquisition by Salmonella ...
P A, Cotter, V J, DiRita
openaire   +2 more sources

Mapping Arenavirus Genes Causing Virulence

1987
The reassortment of genetic information from RNA viruses with segmented genomes, i. e., Arenaviridae, Bunyaviridae, Orthomyxoviridae, and Reoviridae families, can occur within cells infected by two different viral strains from the same family (COmpans etal. 1981; FIelds and GReene 1982; WEbster etal. 1982; Palese 1984).
openaire   +2 more sources

Virulence Gene Regulation in Shigella

EcoSal Plus, 2004
Shigella species are the causative agents of bacillary dysentery in humans, an invasive disease in which the bacteria enter the cells of the epithelial layer of the large intestine, causing extensive tissue damage and inflammation. They rely on a plasmid-encoded type III secretion system (TTSS) to cause disease; this system and
openaire   +2 more sources

CRISPR Gene Editing of a Virulent Bacteriophage

Cold Spring Harbor Protocols, 2023
Genome editing by site-directed mutagenesis is an important tool in biological research. CRISPR gene editing is the latest such tool developed, and one that is widely applicable to study organisms from all kingdoms of life. Here, I introduce a method for making site-directed, defined mutations in a virulent bacteriophage (a bacterial virus) using ...
openaire   +2 more sources

VIRULENCE GENES OFCLOSTRIDIUM PERFRINGENS

Annual Review of Microbiology, 1998
▪ Abstract  Clostridium perfringens causes human gas gangrene and food poisoning as well as several enterotoxemic diseases of animals. The organism is characterized by its ability to produce numerous extracellular toxins including α-toxin or phospholipase C, θ-toxin or perfringolysin O, κ-toxin or collagenase, as well as a sporulation-associated ...
openaire   +2 more sources

Brucella: A pathogen without classic virulence genes

Veterinary Microbiology, 2008
The first species of Brucella was isolated and characterized almost 120 years ago and recently the complete nucleotide sequences of the genomes of a number of well-characterized Brucella strains have been determined. However, compared to other bacterial pathogens relatively little is known about the factors contributing to its persistence in the host ...
Mohamed N, Seleem, Stephen M, Boyle, Nammalwar, Sriranganathan   +2 more
openaire   +2 more sources

Phage regulatory circuits and virulence gene expression

Current Opinion in Microbiology, 2005
In many pathogenic bacteria, genes that encode virulence factors are located in the genomes of prophages. Clearly bacteriophages are important vectors for disseminating virulence genes, but, in addition, do phage regulatory circuits contribute to expression of these genes?
Matthew K, Waldor, David I, Friedman
openaire   +2 more sources

Virulence Gene Expression: Fiat LuxO!

Science Signaling, 2002
Bacteria can monitor their population density through the perception of molecules secreted by other local bacteria. This phenomenon leads to changes in bacterial behavior and changes in gene expression, and is termed quorum sensing. Quorum sensing in Vibrio cholerae , a major pathogenic bacterium in ...
openaire   +2 more sources