Results 141 to 150 of about 2,401,730 (258)

'Yersinia pseudotuberculosis' mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1

, 2010
Manganese has an important yet undefined role in the virulence of many bacterial pathogens. In this study we confirm that a null mutation in Yersinia pseudotuberculosis mntH reduces intracellular manganese accumulation.
Richard W. Titball, Oyston, Petra C. F., Ford, Donna C., Champion, Olivia L., Olivia L. Champion, Andrey Karlyshev, Donna C. Ford, Petra C. F. Oyston, Titball, Richard W., Titball, Richard W, Karlyshev, Andrey, Wren, Brendan W, Champion, Olivia L, Duffield, Melanie, Ian A. M. Cooper, Ford, Donna C, Wren, Brendan W., Oyston, Petra CF, Brendan W. Wren, Cooper, Ian AM, Cooper, A. M., Melanie Duffield   +21 more
core   +1 more source

The Collective Power of Bacteria as a Blueprint for Emergent Intelligence

Advanced Intelligent Systems, EarlyView.
Small cells, powerful collectives. Bacteria demonstrate how sophisticated behaviors can emerge from many simple individuals working together. We explore the remarkable world of bacterial communities and the mechanisms that underpin their complex emergent behaviors, enabling impressive adaptability, robustness, and responsiveness to changing ...
Johanna A. Blee, Thomas E. Gorochowski, Sabine Hauert   +2 more
wiley   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Vibrio cholerae CsrA controls ToxR levels by increasing the stability and translation of toxR mRNA

mBio
Intestinal colonization and virulence factor production in response to environmental cues is mediated through several regulatory factors in Vibrio cholerae, including the highly conserved RNA-binding global regulatory protein CsrA.
Alexandra R. Mey, Charles R. Midgett, F. Jon Kull, Shelley M. Payne   +3 more
doaj   +1 more source

Mechanisms Underlying the Virulence Regulation of Vibrio alginolyticus ND-01 pstS and pstB with a Transcriptomic Analysis. [PDF]

Microorganisms, 2022
Yi X, Xu X, Qi X, Chen Y, Zhu Z, Xu G, Li H, Kraco EK, Shen H, Lin M, Zheng J, Qin Y, Jiang X.   +12 more
europepmc   +1 more source

Host‐Specific Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa Impair Epithelial Repair in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun, Mahnaz Ramezanpour, George Bouras, Emma Barry, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +6 more
wiley   +1 more source

Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections

Angewandte Chemie, EarlyView.
KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran, Axia Marlin, Edith K. Amason, Marie Huynh, Hannah Carlisle, Eszter Boros   +5 more
wiley   +2 more sources

Egy virulencia regulátor mutáns Salmonella enterica törzs mint kereszt-immunitást biztosító orális vakcina jelölt vizsgálata = Investigation of a virulence regulator mutant strain of Salmonella enterica as a candidate for live oral vaccine providing cross-immunity [PDF]

, 2008
Kutatásaink során egy Salmonella rfaH mutánst mint potenciális vakcina jelöltet vizsgáltunk több aspektusból. Mivel az RfaH fehérje egy transzkripciós regulátor, vizsgáltuk, hogy mely virulencia faktorokra kifejtett hatása okozza a vakcina törzs ...
Nagy, Gábor
core   +1 more source

Quorum sensing regulation by the nitrogen phosphotransferase system in Pseudomonas aeruginosa

Journal of Bacteriology
In the opportunistic pathogen Pseudomonas aeruginosa, the nitrogen-related phosphotransferase system (PTSNtr) influences multiple virulence behaviors. The PTSNtr is comprised of three enzymes: first PtsP, then the PtsO phosphocarrier, and the final PtsN ...
Samalee Banerjee, Nicole E. Smalley, Pradtahna Saenjamsai, Anthony R. Fehr, Ajai A. Dandekar, Matthew T. Cabeen, Josephine R. Chandler   +6 more
doaj   +1 more source

The Rcs System in Enterobacteriaceae: Envelope Stress Responses and Virulence Regulation. [PDF]

Front Microbiol, 2021
Meng J, Young G, Chen J.
europepmc   +1 more source