Results 151 to 160 of about 2,401,730 (258)

Refining a preclinical model of viral myocarditis in accordance with biotech standards

Animal Models and Experimental Medicine, EarlyView.
This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H. Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E. Camacho Londoño   +9 more
wiley   +1 more source

The HosA histone deacetylase regulates stress resistance, host cell interactions, and virulence in Aspergillus fumigatus

Microbiology Spectrum
The capacity of Aspergillus fumigatus to cause invasive pulmonary aspergillosis depends on its ability to adapt to dynamic and stressful microenvironments within the host.
Hong Liu, Pamela Lee, Alice Vo, Sanjoy Paul, Quynh T. Phan, Jianfeng Lin, Vincent M. Bruno, Mark A. Stamnes, W. Scott Moye-Rowley, Scott G. Filler   +9 more
doaj   +1 more source

Modulation of AggR levels reveals features of virulence regulation in enteroaggregative E. coli. [PDF]

Commun Biol, 2021
Prieto A, Bernabeu M, Sánchez-Herrero JF, Pérez-Bosque A, Miró L, Bäuerl C, Collado C, Hüttener M, Juárez A.   +8 more
europepmc   +1 more source

The McbR transcription factor links the intracellular folate pool to virulence in enterohemorrhagic Escherichia coli

mBio
Bacterial pathogens coordinate the expression of metabolically expensive virulence programs during host colonization. While the impact of environmental cues on virulence has been extensively studied, direct sensing of metabolic intermediates to inform ...
Quentin Perraud, Vanessa Sperandio
doaj   +1 more source

Co-component signal transduction systems: Fast-evolving virulence regulation cassettes discovered in enteric bacteria. [PDF]

Proc Natl Acad Sci U S A, 2022
Kinch LN, Cong Q, Jaishankar J, Orth K.
europepmc   +1 more source

Quorum-sensing regulator LsrR modulates avian pathogenic Escherichia coli pathogenicity through direct regulation of cysN

Infection and Immunity
Avian Pathogenic Escherichia coli (APEC) is a major cause of economic loss in poultry, exacerbated by the rising prevalence of antibiotic resistance.
Saqib Nawaz, Zhihao Wang, Wei Jiang, Lanfang Kong, Huifang Yin, Yinli Bao, Cuiqin Huang, Zhaoguo Chen, Yan Zhang, Xiangan Han   +9 more
doaj   +1 more source

Deep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation. [PDF]

Front Microbiol, 2023
Anziani P, Becker J, Mignon C, Arnaud-Barbe N, Courtois V, Izac M, Pizzato R, Abi-Ghanem J, Tran VD, Sarafian M, Bunescu A, Garnier D, Abachin E, Renauld-Mongénie G, Guyard C.   +14 more
europepmc   +1 more source

Quorum quenchers affect the virulence regulation of non-mucoid, mucoid and heavily mucoid biofilms co-cultured on cell lines. [PDF]

Appl Microbiol Biotechnol, 2021
Kalgudi R, Tamimi R, Kyazze G, Keshavarz T.   +3 more
europepmc   +1 more source

Virulence Regulation and Innate Host Response in the Pathogenicity of Vibrio cholerae. [PDF]

Front Cell Infect Microbiol, 2020
Ramamurthy T, Nandy RK, Mukhopadhyay AK, Dutta S, Mutreja A, Okamoto K, Miyoshi SI, Nair GB, Ghosh A.   +8 more
europepmc   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source