Results 51 to 60 of about 5,926,013 (258)

Transcriptome analysis of infection of the archaeon Sulfolobus solfataricus with Sulfolobus turreted icosahedral virus [PDF]

, 2008
Microarray analysis of infection by Sulfolobus turreted icosahedral virus (STIV) revealed insights into the timing and extent of virus transcription, as well as differential regulation of host genes. Using a microarray containing genes from both the host
Walther, Jasper, Douglas, Trevor, Brumfield, Susan K., Bothner, Brian, Ortmann, Alice C., McInnerney, Kathleen, Young, Mark J., Brouns, Stan J.J., Van De Werken, Harmen J.G.; id_orcid, Van De Oost, John, Van Der Oost, John, Werken, H.J.G., van de, Brumfield, S.K., Douglas, T., Oost, J., van der, Walther, J., Young, M.J., Ortmann, A.C., Brouns, S.J.J., Bothner, B., McInnerney, K.   +20 more
core   +1 more source

The impact of cytomegalovirus coinfection on tuberculosis in the mouse model

BMC Infectious Diseases
Background Tuberculosis (TB) remains a major global health challenge, with 10.6 million new cases and 1.3 million deaths annually. HIV coinfection is a well-known risk factor in high-burden regions, but emerging evidence suggests that other viral ...
Jaqueline Marschner, Sebastian Marwitz, Lars Eggers, Linda von Borstel, Lara Buer, David Hertz, Torsten Goldmann, Eleonore Ostermann, Wolfram Brune, Bianca E. Schneider   +9 more
doaj   +1 more source

Mosquito Saliva Subunit Vaccine Enhances Efficacy of VLP Vaccines Against Zika and Chikungunya Viruses

Vaccines
Background/Objectives: Mosquito-borne viruses cause substantial global morbidity and mortality. Mosquito saliva, secreted during biting, facilitates blood feeding and can enhance virus infection.
Siân Jossi, Megan Cole, Yonca Keskek Turk, Sam Verwimp, Katrien Trappeniers, James Luk, Joshua X. D. Ang, Luke Alphey, Leen Delang, Clive S. McKimmie, Olga Pleguezuelos   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A high-throughput yeast two-hybrid protocol to determine virus-host protein interactions

, 2022
S.1-15The yeast two-hybrid (Y2H) system is a powerful method to identify and analyze binary protein interactions. In the field of virology, the Y2H system has significantly increased our knowledge of structure and function of viral proteins by ...
Bailer, S., Koegl, M., Striebinger, H.
core   +1 more source

Sand fly saliva reprograms skin fibroblasts to enhance arbovirus infection

iScience
Summary: Arbovirus transmission by sand flies is a growing public health concern, yet the early skin events shaping infection outcomes remain undefined.
Yonca Keskek Turk, Ailish McCafferty-Brown, Liam Barningham, Magdalena Jancarova, Petr Volf, Matthew E. Rogers, Akira J.T. Alexander, Çağdaş Kaya, Sandy MacDonald, Maria Grazia Cusi, Alain Kohl, Kave Shams, Clive S. McKimmie   +12 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

RNA-Protein Interaction Analysis of SARS-CoV-2 5′ and 3′ Untranslated Regions Reveals a Role of Lysosome-Associated Membrane Protein-2a during Viral Infection

mSystems, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-strand RNA virus. The viral genome is capped at the 5′ end, followed by an untranslated region (UTR). There is a poly(A) tail at the 3′ end, preceded by a UTR.
Rohit Verma, Sandhini Saha, Shiv Kumar, Shailendra Mani, Tushar Kanti Maiti, Milan Surjit   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Recognition of human oncogenic viruses by host pattern recognition receptors

Frontiers in Immunology, 2014
Human oncogenic viruses include Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1), Kaposi’s associated sarcoma virus (KSHV), and Merkel cell polyomavirus ...
Nelson C Di Paolo
doaj   +1 more source