Results 211 to 220 of about 5,037,554 (304)

Recent advances in human cytomegalovirus: a comprehensive review of pathogenic mechanisms, virus-host interactions, and antiviral strategies. [PDF]

Front Immunol
Xia Y, Zhang J, Shui X, Wang C, Zhang S, Chai W, Yang Y, Shen L, Wang C.   +8 more
europepmc   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Correction: RBM39 shapes innate immunity by controlling expression of key factors of the interferon response

Frontiers in Immunology
Teng-Feng Li, Paul Rothhaar, Arthur Lang, Oliver Grünvogel, Ombretta Colasanti, Santa Mariela Olivera Ugarte, Jannik Traut, Antonio Piras, Nelson Acosta-Rivero, Vladimir Gonçalves Magalhães, Emely Springer, Andreas Betz, Hao-En Huang, Jeongbin Park, Jeongbin Park, Jeongbin Park, Ruiyue Qiu, Gnimah Eva Gnouamozi, Ann-Kathrin Mehnert, Viet Loan Dao Thi, Viet Loan Dao Thi, Stephan Urban, Stephan Urban, Martina Muckenthaler, Matthias Schlesner, Matthias Schlesner, Dirk Wohlleber, Marco Binder, Ralf Bartenschlager, Ralf Bartenschlager, Ralf Bartenschlager, Andreas Pichlmair, Andreas Pichlmair, Volker Lohmann, Volker Lohmann   +34 more
doaj   +1 more source

Oncogenic Viruses in Organ Transplantation: Implications of Virus-Host Interactions for Cancer Development. [PDF]

Viruses
Seyed-Khorami SM, Azadi A, Habibian A, Hosseini M, Fan X, Soleimanjahi H, Pourkarim MR.   +6 more
europepmc   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Role of Extracellular Vesicles in Severe Dengue: Virus-Host Interactions and Biomarker Potential. [PDF]

Viruses
Agudelo JSH, Pereira G, Fernandes CJDC.
europepmc   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Metagenomic analysis reveals how multiple stressors disrupt virus-host interactions in multi-trophic freshwater mesocosms. [PDF]

Nat Commun
Wang T, Zhang P, Anantharaman K, Wang H, Zhang H, Zhang M, Xu J.   +6 more
europepmc   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source