Results 1 to 10 of about 37,349 (239)

Phenylmethimazole Blocks dsRNA-Induced IRF3 Nuclear Translocation and Homodimerization

Molecules, 2012
Previous studies revealed that phenylmethimazole (C10) inhibits IRF3 signaling, preventing dsRNA-induction of type 1 interferon gene expression, production, and downstream signaling.
Kelly Mccall, Douglas J Goetz, Frank L Schwartz   +2 more
exaly   +4 more sources

DYRK4 upregulates antiviral innate immunity by promoting IRF3 activation

EMBO Reports
Viral infection activates the transcription factors IRF3 and NF-κB, which induce type I interferon (IFN) and antiviral innate immune responses. Here, we identify dual-specific tyrosine phosphorylation-regulated kinase 4 (DYRK4) as an important regulator ...
Mingxiong Guo, Guihong Sun
exaly   +3 more sources

EBV (LMP1) enhances cisplatin resistance by enhancing degradation of interferon regulatory factor 3 [PDF]

Cell Communication and Signaling
EBV employs multiple strategies to subvert host innate immunity, including suppression of type I IFN signaling. However, the precise mechanism by which its latent oncoprotein LMP1 modulates this pathway in nasopharyngeal carcinoma (NPC) remains unclear ...
Yueshuo Li, Na Liu, Chenxing Yang, Shan He, Cheng Luo, Lin Wang, Min Tang, Xiangjian Luo, Ya Cao, Li Shang, Feng Shi   +10 more
doaj   +2 more sources

Cytoplasmic retention of IRF3 binding Vimentin competitively with ERK1/2 mitigates acute myeloid leukemia through TFEB nuclear translocation [PDF]

Cell Communication and Signaling
Acute myeloid leukemia (AML) is characterized by the accumulation of immature myeloid blasts. In this study, we investigated the role of interferon regulatory factor 3 (IRF3), a key transcription factor of type I interferon, in AML differentiation.
Manman Geng, Aili He, Qiaoyan Jin, Dongxia Liang, Xiaoyu Ren, Xiaomeng Li, Yanglong Guan, Chongyu Zhang, Yaqi Lu, Jing Zhang, Wentao Zhang, Yuanyuan Cheng, Yingnan Li, Yuanshuo Ouyang, Kewei Chang, Liesu Meng, Wenhua Zhu, Shemin Lu   +17 more
doaj   +2 more sources

Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages [PDF]

EMBO Reports
STING is an important component in the host innate immune system where its activation by cyclic dinucleotides culminates in the production of interferons and pro-inflammatory cytokines that mediate host defence against infection.
Katherine R Balka, Olivia R Lamb, Rajan Venkatraman, Zoe Magill, Le T Hoang, Ryker Dumbrill, Kate McArthur, Nicole A de Weerd, Paul J Hertzog, Peter J Crack, Linda M Wakim, Kim L Good-Jacobson, Mireille H Lahoud, Meredith O’Keeffe, Dominic De Nardo   +14 more
doaj   +2 more sources

INPP5D inhibits anti-malarial immunity by promoting IRF3 degradation through selective autophagy

Autophagy Reports, 2023
As a member of the inositol polyphosphate-5-phosphatase family, INPP5D (inositol polyphosphate-5-phosphatase D) is an important regulator of immune cell activation. To date, the mechanisms underlying anti-malarial immunity have not been elucidated.
Hongyu Li, Xiao Yu
doaj   +1 more source

Serine-arginine splicing factor 2 promotes oesophageal cancer progression by regulating alternative splicing of interferon regulatory factor 3

RNA Biology, 2023
Objective Often, alternative splicing is used by cancer cells to produce or increase proteins that promote growth and survival through alternative splicing.
Ziqing Wei, Yuyao Wang, Wenyuan Ma, Wenqing Xing, Peng Lu, Zhijie Shang, Feng Li, Huiyu Li, Yuxuan Wang   +8 more
doaj   +1 more source

Autophagic checks and balances of cellular immune responses

Autophagy Reports, 2022
IRF3 (interferon regulatory factor 3) is a critical component of the antiviral innate immune response. IRF3 deficiency causes detrimental effects to the host during virus infection.
Sukanya Chakravarty, Shumin Fan, Ritu Chakravarti, Saurabh Chattopadhyay   +3 more
doaj   +1 more source

Transcriptional and Non-Transcriptional Activation, Posttranslational Modifications, and Antiviral Functions of Interferon Regulatory Factor 3 and Viral Antagonism by the SARS-Coronavirus

Viruses, 2021
The immune system defends against invading pathogens through the rapid activation of innate immune signaling pathways. Interferon regulatory factor 3 (IRF3) is a key transcription factor activated in response to virus infection and is largely responsible
Anna Glanz, Sukanya Chakravarty, Merina Varghese, Anita Kottapalli, Shumin Fan, Ritu Chakravarti, Saurabh Chattopadhyay   +6 more
doaj   +1 more source

IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation

Cell Reports, 2021
Summary: Interferon regulatory factor 3 (IRF3) is an essential transductor for initiation of many immune responses. Here, we show that lncRNA-ISIR directly binds IRF3 to promote its phosphorylation, dimerization, and nuclear translocation, along with ...
Junfang Xu, Pin Wang, Zemeng Li, Zhiqing Li, Dan Han, Mingyue Wen, Qihang Zhao, Lianfeng Zhang, Yuanwu Ma, Wei Liu, Minghong Jiang, Xuan Zhang, Xuetao Cao   +12 more
doaj   +1 more source