Results 1 to 10 of about 31,517 (112)

YWHAZ downregulated innate immune responses to RNA viruses by inhibiting the IRF3 signaling pathway [PDF]

mSphere
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide (YWHAZ) is a member of the YWHA/14-3-3 family. YWHAZ is highly conserved in mammalian cells and generally mediates signal transduction through direct interactions ...
Shasha Li, Jinyuan Han, Hefei Wang, Jixia Hou, Linhao Wang, Zhengyang Hou, Yaxin Zhang, Xueer Dou, Jingying Xie, Huixia Li, Xiangrong Li, Ruofei Feng   +11 more
doaj   +2 more sources

Phenylmethimazole Blocks dsRNA-Induced IRF3 Nuclear Translocation and Homodimerization

Molecules, 2012
Previous studies revealed that phenylmethimazole (C10) inhibits IRF3 signaling, preventing dsRNA-induction of type 1 interferon gene expression, production, and downstream signaling.
Noriko Kantake, Douglas J Goetz, Frank L Schwartz   +2 more
exaly   +3 more sources

Cytoplasmic retention of IRF3 binding Vimentin competitively with ERK1/2 mitigates acute myeloid leukemia through TFEB nuclear translocation [PDF]

Cell Communication and Signaling
Acute myeloid leukemia (AML) is characterized by the accumulation of immature myeloid blasts. In this study, we investigated the role of interferon regulatory factor 3 (IRF3), a key transcription factor of type I interferon, in AML differentiation.
Manman Geng, Aili He, Qiaoyan Jin, Dongxia Liang, Xiaoyu Ren, Xiaomeng Li, Yanglong Guan, Chongyu Zhang, Yaqi Lu, Jing Zhang, Wentao Zhang, Yuanyuan Cheng, Yingnan Li, Yuanshuo Ouyang, Kewei Chang, Liesu Meng, Wenhua Zhu, Shemin Lu   +17 more
doaj   +2 more sources

Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages [PDF]

EMBO Reports
STING is an important component in the host innate immune system where its activation by cyclic dinucleotides culminates in the production of interferons and pro-inflammatory cytokines that mediate host defence against infection.
Katherine R Balka, Olivia R Lamb, Rajan Venkatraman, Zoe Magill, Le T Hoang, Ryker Dumbrill, Kate McArthur, Nicole A de Weerd, Paul J Hertzog, Peter J Crack, Linda M Wakim, Kim L Good-Jacobson, Mireille H Lahoud, Meredith O’Keeffe, Dominic De Nardo   +14 more
doaj   +2 more sources

IRF3 Negatively Regulates Toll-Like Receptor-Mediated NF-κB Signaling by Targeting TRIF for Degradation in Teleost Fish

Frontiers in Immunology, 2018
NF-κB signaling is tightly regulated and essential to innate and adaptive immune responses, its regulatory mechanism remains unclear in various organisms, especially teleosts.
Xueyan Zhao, Ruixuan Huo, Tianjun Xu
exaly   +3 more sources

Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure [PDF]

Nature Communications
Heightened sterile inflammation and mitochondrial metabolic dysfunction drives the pathophysiology of heart failure in ischemic cardiomyopathy. Yet, the transcriptional regulators within cardiomyocytes driving crosstalk between inflammation and energy ...
Manju Kumari, Ioannis Evangelakos, Anushka Deshpande, Kirstie A. De Jong, Nesrin Schmiedel, Nicolàs Palacio-Escat, Adriano de Britto Chaves-Filho, Roberto Carlos Frias-Soler, Glynis Klinke, Hyun Cheol Roh, Luisa Lange, Michael Berlin, Marceline M. Fuh, Jakob Johannes Buss, Tian Tian, Carolin Lerchenmüller, Marc Freichel, Almut Schulze, Viacheslav O. Nikolaev, Thomas Eschenhagen, Evan D. Rosen, Ludger Scheja, Ashraf Yusuf Rangrez, Joerg Heeren, Norbert Frey   +24 more
doaj   +2 more sources

Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense

Advanced Science
Interferons (IFNs) activate JAK‐STAT pathways to induce downstream effector genes for host defense against invaded pathogens and tumors. Here both type I (β) and II (γ) IFNs are shown that can activate the transcription factor IRF3 in parallel with STAT1.
Su-Yun Wang, Wei-Wei Luo, Yan-Yi Wang
exaly   +2 more sources

INPP5D inhibits anti-malarial immunity by promoting IRF3 degradation through selective autophagy

Autophagy Reports, 2023
As a member of the inositol polyphosphate-5-phosphatase family, INPP5D (inositol polyphosphate-5-phosphatase D) is an important regulator of immune cell activation. To date, the mechanisms underlying anti-malarial immunity have not been elucidated.
Hongyu Li, Xiao Yu
doaj   +1 more source

Serine-arginine splicing factor 2 promotes oesophageal cancer progression by regulating alternative splicing of interferon regulatory factor 3

RNA Biology, 2023
Objective Often, alternative splicing is used by cancer cells to produce or increase proteins that promote growth and survival through alternative splicing.
Ziqing Wei, Yuyao Wang, Wenyuan Ma, Wenqing Xing, Peng Lu, Zhijie Shang, Feng Li, Huiyu Li, Yuxuan Wang   +8 more
doaj   +1 more source

Autophagic checks and balances of cellular immune responses

Autophagy Reports, 2022
IRF3 (interferon regulatory factor 3) is a critical component of the antiviral innate immune response. IRF3 deficiency causes detrimental effects to the host during virus infection.
Sukanya Chakravarty, Shumin Fan, Ritu Chakravarti, Saurabh Chattopadhyay   +3 more
doaj   +1 more source