Results 41 to 50 of about 37,349 (239)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Interferon Regulatory Factor 3 Deficiency Induces Age-Related Alterations of the Retina in Young and Old Mice

Frontiers in Cellular Neuroscience, 2019
Age-related changes in visual function and retina structure are very common in aged animals, but the underlying mechanisms of these changes remain unclear.
Xi Zhang, Jingyi Zhu, Xianjun Chen, Zhang Jie-Qiong, Xue Li, Linlin Luo, Huang Huang, Wenyi Liu, Xinyuan Zhou, Jun Yan, Sen Lin, Jian Ye   +11 more
doaj   +1 more source

Characterization of Fish IRF3 as an IFN-Inducible Protein Reveals Evolving Regulation of IFN Response in Vertebrates [PDF]

, 2010
In mammals, IFN regulatory factor (IRF) 3 is a critical player in modulating transcription of type I IFN and IFN-stimulated genes (ISGs). In this study, we describe the roles of crucian carp (Carassius auratus L.) IRF3 in activating fish IFN and ISGs ...
Yu, Fei-Fei, Liu, Ying, Zhang, YB, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Grad Sch, Wuhan 430072, Peoples R China, Zhang, Yi-Bing, Gan, Li, Sun, Fan, Gui, Jian-Fang, Liu, Ting-Kai   +7 more
core  

TRIM26 targets IRF3.

, 2015
(A) HEK293/TLR3 and HEK293/TLR4 or Hela cells were transfected with ISRE reporter plasmid together with TRIM26 expression plasmid or control plasmid, analyzed luciferase activity after treatment with indicated agonists.
Kai Zhao (53042), Lei Zhang (38117), Wei Zhao (14321), Chengjiang Gao (701349), Peng Wang (34436)   +4 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Exploratory study of interferon regulatory factor 3 promoting proliferation and invasion related to colorectal cancer cells

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To analyze the relationship between the expression level of interferon regulatory factor 3 (IRF3) in colorectal cancer and its clinicopathological features and prognosis, and to observe the effects of IRF3 overexpression on the proliferation ...
XU Wenhui, YANG Chang, LI Ruiqing, BIAN Jing, LI Xiayi, ZHENG Leizhen   +5 more
doaj   +1 more source

Human OTUD6B positively regulates type I IFN antiviral innate immune responses by deubiquitinating and stabilizing IRF3

mBio, 2023
Elaborate regulation of innate immunity is necessary for the host to effectively respond to invading pathogens. As an important component of antiviral immunity transcription factors, the stability and activity of interferon (IFN) regulatory factor 3 ...
Jian Wang, Hui Zheng, Chunsheng Dong, Sidong Xiong   +3 more
doaj   +1 more source

Nuclear translocation promotes TRIM26-mediated IRF3 degradation.

, 2015
(A) Western blot analysis of IRF3 expression in HEK293 cells transfected with expression plasmids for Myc-IRF3 WT, KR77/78NG, 5D or 5D KR77/78NG and Flag-TRIM26.
Kai Zhao (53042), Lei Zhang (38117), Wei Zhao (14321), Chengjiang Gao (701349), Peng Wang (34436)   +4 more
core   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source