Results 31 to 40 of about 37,349 (239)
ATRX interacts with IRF3 and modulates IRF3 activity.
, 2022 Stable ATRX knockdown HFFs (siATRX) and respective control HFFs (siC) were (A) treated with DMSO and 0.1 μg/ml poly(dA:dT) for 24 h, (B) treated with 50 μg/ml 2’3’-cGAMP for 24 h, (C) infected with the laboratory HCMV strain AD169 (MOI of 1) for 8 h or ...
Hans A. Kestler (7153568) +5 more
core +1 more source
Viruses, 2020 Interferon (IFN) regulatory factor 3 (IRF3) is the key transcription factor for the induction of IFN and antiviral genes. The absence of antiviral genes in IRF3 deficiency leads to susceptibility to a wide range of viral infections.
Anna Glanz +9 more
doaj +1 more source
CC071 Irf3 mRNAs show abnormal splicing, resulting in defective IRF3 protein.
, 2023 (A) Schematic representation of the exons of the Irf3 gene with the number of reads spanning successive exons in the CC001 and CC071 RNAseq data (one sample of each strain).
Etienne Kornobis (9451023) +6 more
core +1 more source
Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii.
PLoS Pathogens, 2015 Innate immunity is the first line of defense against microbial insult. The transcription factor, IRF3, is needed by mammalian cells to mount innate immune responses against many microbes, especially viruses.
Tanmay Majumdar +6 more
doaj +1 more source
PLoS Pathogens, 2023 Viral infection triggers the activation of transcription factor IRF3, and its activity is precisely regulated for robust antiviral immune response and effective pathogen clearance.
Wei-Wei Li +9 more
doaj +1 more source
Thogoto virus ML protein suppresses IRF3 function [PDF]
, 2004 The Thogoto virus (THOV) is a member of the family Orthomyxoviridae. It prevents induction of alpha/beta interferons (IFN) in cell culture and in vivo via the action of the viral ML protein. Phenotypically, the effect of THOV ML resembles that of the NS1
García-Sastre, Adolfo +9 more
core +1 more source
PLoS ONE, 2011 The innate immune response constitutes the first line of host defence that limits viral spread and plays an important role in the activation of adaptive immune response.
Patricia Vandevenne +8 more
doaj +1 more source
IRF3 physically interacts with ORF47p.
, 2013 HEK-293 cells were transfected either with HA-tagged ORF47 or V5-tagged IRF3 or co-transfected with both plasmids. 24 hours later, cells were infected or not with the mutant VZV ROka47S for another 24 hours. Either IRF3 or HA-ORF47 was immunoprecipitated
Jacques Piette (56234) +8 more
core +1 more source
BLK mediates tyrosine phosphorylation of IRF3, related to Fig 6.
, 2023 (A) The expression levels of BLK and BLK(K269A). U87MG cells (2 × 105) were transfected with BLK or BLK(K269A) plasmids for 24 h. Cells were then harvested for immunoblot analysis. (B) BLK mediates tyrosine phosphorylation of IRF3. HEK293 cells (2 × 106)
Ji-Yan Zhang (551912) +9 more
core +1 more source
RNF138 Downregulates Antiviral Innate Immunity by Inhibiting IRF3 Activation
, 2023 A viral infection activates the transcription factors IRF3 and NF-κB, which synergistically induces type I interferons (IFNs). Here, we identify the E3 ubiquitin ligase RNF138 as an important negative regulator of virus-triggered IRF3 activation ...
Chaozhi Liu +5 more
core +1 more source