Results 11 to 20 of about 31,611 (205)

Transcriptional and Non-Transcriptional Activation, Posttranslational Modifications, and Antiviral Functions of Interferon Regulatory Factor 3 and Viral Antagonism by the SARS-Coronavirus

Viruses, 2021
The immune system defends against invading pathogens through the rapid activation of innate immune signaling pathways. Interferon regulatory factor 3 (IRF3) is a key transcription factor activated in response to virus infection and is largely responsible
Anna Glanz, Sukanya Chakravarty, Merina Varghese, Anita Kottapalli, Shumin Fan, Ritu Chakravarti, Saurabh Chattopadhyay   +6 more
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IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation

Cell Reports, 2021
Summary: Interferon regulatory factor 3 (IRF3) is an essential transductor for initiation of many immune responses. Here, we show that lncRNA-ISIR directly binds IRF3 to promote its phosphorylation, dimerization, and nuclear translocation, along with ...
Junfang Xu, Pin Wang, Zemeng Li, Zhiqing Li, Dan Han, Mingyue Wen, Qihang Zhao, Lianfeng Zhang, Yuanwu Ma, Wei Liu, Minghong Jiang, Xuan Zhang, Xuetao Cao   +12 more
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siRNAs to Knockdown Antiviral Chemokine-related Genes in FRhK-4 Cells

Journal of Food Protection, 2023
The objective of this study was to generate small interfering RNA (siRNA) to knockdown antiviral chemokine-related genes in fetal rhesus monkey kidney (FRhK-4) cells.
Eunyoung Park, Yoonjeong Yoo, Sangeun Park, Changsun Choi, Yohan Yoon   +4 more
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PP2A Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication by Deactivating irf3 and Limiting Type I Interferon Production

Viruses, 2019
Protein phosphatase 2A (PP2A), a major serine/threonine phosphatase in mammalian cells, is known to regulate the kinase-driven intracellular signaling pathways.
Jiayu Xu, Lu Zhang, Yunfei Xu, He Zhang, Junxin Gao, Qian Wang, Zhijun Tian, Lv Xuan, Hongyan Chen, Yue Wang   +9 more
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Lack of interferon regulatory factor 3 leads to anxiety/depression-like behaviors through disrupting the balance of neuronal excitation and inhibition in mice

Genes and Diseases, 2023
Disrupting the balance of neuronal excitation and inhibition (E/I) is an important pathogenic mechanism of anxiety and depression. Interferon regulatory factor 3 (IRF3) plays a key role in the innate immune response, and activation of IRF3 triggers the ...
Junjie Li, Yayan Pang, Yehong Du, Lei Xia, Mulan Chen, Yepeng Fan, Zhifang Dong   +6 more
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HSPD1 interacts with IRF3 to facilitate interferon-beta induction. [PDF]

PLoS ONE, 2014
The production of IFN- I (IFN-α/β) is one of the earliest and most important host-protective responses. Interferon regulatory factor 3 (IRF3) is a critical transcriptional factor in the IFN-β signaling pathway.
Lan Lin, Shan Pan, Jianqing Zhao, Cheng Liu, Pingan Wang, Lei Fu, Xinlin Xu, Meilin Jin, Anding Zhang   +8 more
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IRF3 Activation in Mast Cells Promotes FcεRI-Mediated Allergic Inflammation

Cells, 2023
(1) Background: This study aims to elucidate a novel non-transcriptional action of IRF3 in addition to its role as a transcription factor in mast cell activation and associated allergic inflammation; (2) Methods: For in vitro experiments, mouse bone ...
Young-Ae Choi, Hima Dhakal, Soyoung Lee, Namkyung Kim, Byungheon Lee, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim   +7 more
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IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin

Nature Communications, 2020
Occurrence of Colorectal cancer (CRC) is relevant with gut microbiota. However, role of IRF3, a key signaling mediator in innate immune sensing, has been barely investigated in CRC.
Miao Tian, Xiumei Wang, Jihong Sun, Wenlong Lin, Lumin Chen, Shengduo Liu, Ximei Wu, Liyun Shi, Pinglong Xu, Xiujun Cai, Xiaojian Wang   +10 more
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Nontranscriptional Activity of Interferon Regulatory Factor 3 Protects Mice From High‐Fat Diet‐Induced Liver Injury

Hepatology Communications, 2019
Interferon regulatory factor 3 (IRF3) has both transcriptional and nontranscriptional functions. Transcriptional activity is dependent on serine phosphorylation of IRF3, while transcription‐independent IRF3‐mediated apoptosis requires ubiquitination ...
Carlos Sanz‐Garcia, Megan R. McMullen, Saurabh Chattopadhyay, Sanjoy Roychowdhury, Ganes Sen, Laura E. Nagy   +5 more
doaj   +1 more source

TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3.

PLoS Pathogens, 2015
Virus infection leads to the activation of transcription factor IRF3 and subsequent production of type I inteferons, which induce the transcription of various antiviral genes called interferon stimulated genes (ISGs) to eliminate viral infection.
Peng Wang, Wei Zhao, Kai Zhao, Lei Zhang, Chengjiang Gao   +4 more
doaj   +1 more source