Results 11 to 20 of about 37,349 (239)

IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer’s disease [PDF]

Journal of Neuroinflammation
The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific role of Interferon Regulatory Factor 3 (IRF3) in neuroinflammation remains poorly understood.
Radhika Joshi, Veronika Brezani, Gabrielle M. Mey, Sergi Guixé-Muntet, Marti Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, Gyongyi Szabo   +9 more
doaj   +3 more sources

HSPD1 interacts with IRF3 to facilitate interferon-beta induction. [PDF]

PLoS ONE, 2014
The production of IFN- I (IFN-α/β) is one of the earliest and most important host-protective responses. Interferon regulatory factor 3 (IRF3) is a critical transcriptional factor in the IFN-β signaling pathway.
Lan Lin, Shan Pan, Jianqing Zhao, Cheng Liu, Pingan Wang, Lei Fu, Xinlin Xu, Meilin Jin, Anding Zhang   +8 more
doaj   +2 more sources

TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3.

PLoS Pathogens, 2015
Virus infection leads to the activation of transcription factor IRF3 and subsequent production of type I inteferons, which induce the transcription of various antiviral genes called interferon stimulated genes (ISGs) to eliminate viral infection.
Peng Wang, Wei Zhao, Kai Zhao, Lei Zhang, Chengjiang Gao   +4 more
doaj   +2 more sources

Pseudorabies Virus US3 Protein Inhibits IFN-β Production by Interacting With IRF3 to Block Its Activation [PDF]

, 2021
Pseudorabies virus is a typical swine alphaherpesvirus, which can cause obvious neurological disorders and reproductive failure in pigs. It is capable of evading host antiviral immune response. However, the mechanism by which many PRV proteins assist the
Lei Chen, Xie, Jingying, Ruofei Feng, Chen, Lei, Idris, Adi, Yong Zhang, Shujuan Xu, Zhang, Xiangbo, Xiangbo Zhang, Xu, Shujuan, Adi Idris, Bi, Yingjie, Feng, Ruofei, Li, Xiangrong, Jingying Xie, Yingjie Bi, Xiangrong Li, Zhang, Yong   +17 more
core   +1 more source

siRNAs to Knockdown Antiviral Chemokine-related Genes in FRhK-4 Cells

Journal of Food Protection, 2023
The objective of this study was to generate small interfering RNA (siRNA) to knockdown antiviral chemokine-related genes in fetal rhesus monkey kidney (FRhK-4) cells.
Eunyoung Park, Yoonjeong Yoo, Sangeun Park, Changsun Choi, Yohan Yoon   +4 more
doaj   +1 more source

BLK associates with IRF3.

, 2023
(A) Identification of the BLK interactome by silver staining and mass spectrometry methods. Silver staining showing GST-associated factors (Control) and GST-BLK-associated factors. IRF3 was one of the convincing interacting factors.
Ji-Yan Zhang (551912), Hai-Xue Zheng (544167), Zi-Xiang Zhu (17271371), Yi-Zhuo Wang (9724460), Xu-Xu Fan (17271368), Yan-Yi Wang (3930020), Dan-Shi Pei (17271380), Wei-Wei Li (276638), Xue-Jing Cao (17271374), Zhao-Yu Zhu (17271377)   +9 more
core   +1 more source

NSD3 keeps IRF3 active [PDF]

, 2017
In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20170856) show a novel antiviral innate mechanism by which methyltransferase NSD3 directly monomethylates a transcription factor IRF3 and maintains IRF3 phosphorylation to enhance its ...
Takeuchi Osamu, Mino, Takashi
core   +2 more sources

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A.   +24 more
core   +1 more source

NOG1 interacts with phosphorylated IRF3.

, 2023
(A-B) HEK-293T cells were transfected with 3 μg of Flag-NOG1 expression plasmid along with 3 μg of HA empty vector, HA-IRF3, or HA-IRF3 5D expression plasmids.
Weijun Cao (122575), Haixue Zheng (286790), Zixiang Zhu (280085), Fan Yang (1413), Huisheng Liu (408091), Xiangtao Liu (286800), Qiao Xue (431091), Zhaoning Xue (14564656)   +7 more
core   +1 more source

PP2A Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication by Deactivating irf3 and Limiting Type I Interferon Production

Viruses, 2019
Protein phosphatase 2A (PP2A), a major serine/threonine phosphatase in mammalian cells, is known to regulate the kinase-driven intracellular signaling pathways.
Jiayu Xu, Lu Zhang, Yunfei Xu, He Zhang, Junxin Gao, Qian Wang, Zhijun Tian, Lv Xuan, Hongyan Chen, Yue Wang   +9 more
doaj   +1 more source