Results 21 to 30 of about 37,349 (239)

Lack of interferon regulatory factor 3 leads to anxiety/depression-like behaviors through disrupting the balance of neuronal excitation and inhibition in mice

Genes and Diseases, 2023
Disrupting the balance of neuronal excitation and inhibition (E/I) is an important pathogenic mechanism of anxiety and depression. Interferon regulatory factor 3 (IRF3) plays a key role in the innate immune response, and activation of IRF3 triggers the ...
Junjie Li, Yayan Pang, Yehong Du, Lei Xia, Mulan Chen, Yepeng Fan, Zhifang Dong   +6 more
doaj   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation. [PDF]

Adv Sci (Weinh)
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Xie L, Huang Z, Zhang Z, Zhu Y, Liu X, Wang L, Bi T, Liang T, Lai J, Hu M, Qiu G, Xiao S, Liu S, Liu Y, Rao H, Chen T, Peng H, Zhang B, Tang J, Li Q, Li Y, Hou Y, Yang W, Jiang H, Ma X.   +24 more
europepmc   +2 more sources

IRF3 Activation in Mast Cells Promotes FcεRI-Mediated Allergic Inflammation

Cells, 2023
(1) Background: This study aims to elucidate a novel non-transcriptional action of IRF3 in addition to its role as a transcription factor in mast cell activation and associated allergic inflammation; (2) Methods: For in vitro experiments, mouse bone ...
Young-Ae Choi, Hima Dhakal, Soyoung Lee, Namkyung Kim, Byungheon Lee, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim   +7 more
doaj   +1 more source

D4F-Functionalized Ceria Nanozyme-CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury. [PDF]

Adv Sci (Weinh)
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Chen W, Li M, Wang X, Sun J, Zhang Z, Gong Y, Shi B, Yu N, Mao Y, Zhao S, Zhang X, Guo L.   +11 more
europepmc   +2 more sources

S-glutathionylation of IRF3 regulates IRF3-CBP interaction and activation of the IFN beta pathway [PDF]

, 2008
Interferon regulatory factor 3 (IRF3) is an essential transcriptional regulator of the interferon genes. IRF3 is constitutively present in a latent conformation in the cell cytoplasm.
Thanos, Dimitris, Spyrou, Giannis, Chantzoura, Eleni,, Thanos, Dimitris,, Chantzoura, Eleni, Spyrou, Giannis,, Prinarakis, Efthimios, Prinarakis, Efthimios,   +7 more
core   +1 more source

MORC3 promotes degradation of IRF3.

, 2023
(A) The subcellular distribution of MORC3 in EPC cells was examined by immunofluorescence. Scale bars = 10 μm. (B) Immunoprecipitation analysis of the interaction between MORC3 and IRF3 in HEK293 cells transfected with MORC3-Myc and IRF3-Flag plasmids ...
Weiwei Zheng (140828), Linchao Wang (17706020), Tianjun Xu (138445), Yanhong Song (4516555), Xing Lv (277606)   +4 more
core   +1 more source

IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin

Nature Communications, 2020
Occurrence of Colorectal cancer (CRC) is relevant with gut microbiota. However, role of IRF3, a key signaling mediator in innate immune sensing, has been barely investigated in CRC.
Miao Tian, Xiumei Wang, Jihong Sun, Wenlong Lin, Lumin Chen, Shengduo Liu, Ximei Wu, Liyun Shi, Pinglong Xu, Xiujun Cai, Xiaojian Wang   +10 more
doaj   +1 more source

Nontranscriptional Activity of Interferon Regulatory Factor 3 Protects Mice From High‐Fat Diet‐Induced Liver Injury

Hepatology Communications, 2019
Interferon regulatory factor 3 (IRF3) has both transcriptional and nontranscriptional functions. Transcriptional activity is dependent on serine phosphorylation of IRF3, while transcription‐independent IRF3‐mediated apoptosis requires ubiquitination ...
Carlos Sanz‐Garcia, Megan R. McMullen, Saurabh Chattopadhyay, Sanjoy Roychowdhury, Ganes Sen, Laura E. Nagy   +5 more
doaj   +1 more source

Biochemical Analysis of Caspase-8-dependent Proteolysis of IRF3 in Virus-infected Cells

Bio-Protocol, 2016
Interferon regulatory factor 3 (IRF3) is a transcription factor, which is critical for the antiviral response against a wide range of viruses (Hiscott, 2007; Ikushima et al., 2013). It gets activated in virus-infected cells via Toll like receptors (TLRs),
Gayatri Subramanian, Karen Pan, Ritu Chakravarti, Saurabh Chattopadhyay   +3 more
doaj   +1 more source

Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis

Journal of Innate Immunity, 2023
The cytosolic viral nucleic acid-sensing pathways converge on the protein kinase TANK-binding kinase 1 (TBK1) and the transcription factor interferon (IFN)-regulatory factor 3 (IRF3) to induce type I IFN production and antiviral immune responses. However,
Xiaogang Luo, Ruihua Ji, Qianru Liu, Xiaoxue Xiao, Wengang Song, Huazhang An, Yingke Li, Jun Zhou   +7 more
doaj   +1 more source