Results 251 to 260 of about 487,341 (302)
Advanced Intelligent Discovery, EarlyView.This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah +3 more
wiley +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi +6 more
wiley +1 more source
Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco +2 more
wiley +1 more source
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Annual Review of Plant Physiology and Plant Molecular Biology, 1987
INTRODUCTION . HOST RANGE . PLANT-TO-PLANT SPREAD . EARLY EVENTS IN THE PLANT.. . Uncoating . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Gene Expression and Replication . SPREAD OF VIRUSES WITHIN THE PLANT .
M Zaitlin, R Hull
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INTRODUCTION . HOST RANGE . PLANT-TO-PLANT SPREAD . EARLY EVENTS IN THE PLANT.. . Uncoating . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Gene Expression and Replication . SPREAD OF VIRUSES WITHIN THE PLANT .
M Zaitlin, R Hull
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The Obstetrician & Gynaecologist, 2003
The co‐existence of viruses with their hosts can be viewed as a molecular arms race between the virus and host elimination mechanisms. Continuous interactions between hosts and pathogens, during their co‐evolution, have shaped the immune system and in turn viruses have manipulated host immune control mechanisms to facilitate their propagation. As viral
Justin Stebbing, Brian Gazzard
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The co‐existence of viruses with their hosts can be viewed as a molecular arms race between the virus and host elimination mechanisms. Continuous interactions between hosts and pathogens, during their co‐evolution, have shaped the immune system and in turn viruses have manipulated host immune control mechanisms to facilitate their propagation. As viral
Justin Stebbing, Brian Gazzard
openaire +1 more source
Virus–host interactions under hypoxia
Microbes and Infection, 2017Oxygen tension can exert a significant effect on viral propagation in vitro and possibly in vivo. In general, hypoxia restricts the replication of viruses that naturally infect tissues exposed to ambient oxygen and induces the growth of viruses that naturally target tissues exposed to low oxygen.
Niki, Vassilaki, Efseveia, Frakolaki
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Chikungunya virus: host pathogen interaction
Reviews in Medical Virology, 2011AbstractChikungunya is a re‐emerging arthropod‐borne viral disease caused by Chikungunya virus (CHIKV) belonging to the Togaviridae family of genus Alphavirus. It is a virus with a single stranded, positive sense RNA, as its genome. It is maintained in a sylvatic and urban cycle involving humans and the mosquito species Aedes aegypti and Aedes ...
Sunit Kumar, Singh +1 more
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Understanding virus–host interactions in tissues
Nature Microbiology, 2023Although virus-host interactions are usually studied in a single cell type using in vitro assays in immortalized cell lines or isolated cell populations, it is important to remember that what is happening inside one infected cell does not translate to understanding how an infected cell behaves in a tissue, organ or whole organism.
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Virus–host interactions in salt lakes
Current Opinion in Microbiology, 2007Natural hypersaline waters are widely distributed around the globe, as both continental surface waters and sea floor lakes, the latter being maintained by the large density difference between the hypersaline and overlying marine water. Owing to the extreme salt concentrations, close to or at saturation (approximately 35%, w/v), such waters might be ...
Kate, Porter +2 more
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