Results 161 to 170 of about 6,581,491 (250)

Virus-like particles in cancer immunotherapy: bridging human and veterinary medicine through one health. [PDF]

J Nanobiotechnology
Zhu Y, Bi Z, Zhang Z, Zhang M, Du Q, Hu M, Zhou T, Fan Y, Zhang S, Wang G, Liu G.   +10 more
europepmc   +1 more source

A new antiserum for the detection of plum bark necrosis stem pitting-associated virus by mean of ELISA

, 2006
POTERE O, BOSCIA D, CASTELLANO M. A, SAVINO, Vito Nicola   +3 more
core  

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Immunization with Virus-Like Particles Displaying Ara h 2‑Derived Peptides to Mitigate Peanut Allergy. [PDF]

ACS Nano Med
Smeekens JM, Jenkins MC, Carl K, Humphrey JR, Turner AV, Krempski JW, Maleki SJ, Podilapu AR, Vickery BP, Finn MG, Kulis MD.   +10 more
europepmc   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Evaluation of a Zika virus-like particle-based vaccine in a highly penetrant non-human primate model of congenital infection. [PDF]

PLoS Negl Trop Dis
Jaeger HK, Smith JL, Labriola CS, Pung LJ, Hagen OL, Denton M, D'Mello RJ, Parkins CJ, Weber WC, Medica S, Kreklywich CN, DeFilippis VR, Bondoc S, Busman-Sahay K, Castro JN, Zilverberg G, White R, Terry M, Barber-Axthelm AM, Axthelm MK, Smedley J, Aliota MT, Weiler AM, Friedrich TC, Estes J, Morgan TK, Lo JO, Roberts VHJ, Streblow DN, Hirsch AJ.   +29 more
europepmc   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Structural basis and immunogenic efficacy of porcine circovirus type 3 virus-like particle. [PDF]

Nat Commun
Su J, Tong X, Jiang Y, Li Y, Yan H, Liu Y, Wang Y, Su X, Sun Z, Wang M, Xia N, Bostina M, Li S, Pang W, Zheng Q, Tian K.   +15 more
europepmc   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Development and Immunogenicity Evaluation of Baculovirus-Expressed Feline Bocavirus VP2 Virus-like Particles Vaccine in a Mouse Model. [PDF]

Microorganisms
Xing JY, Fu ZX, Xu WJ, Li JY, Wang ZJ, Xiang YX, Wang J, Ming SL, Zheng YT, Li JL, Zeng L.   +10 more
europepmc   +1 more source